Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health.

Q1 Medicine

Current Pathobiology Reports Pub Date : 2018-01-01 Epub Date: 2018-01-20 DOI:10.1007/s40139-018-0159-9

Lei Lu, Erika C Claud

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Abstract

Purpose of review: Significant research reveals that the microbiome modulates perinatal and postnatal health. This review aims to examine mechanisms by which intrauterine infection, the epigenome, and microbiome specifically influence preterm infant health outcomes.

Recent findings: Intrauterine infection is a primary cause of preterm birth and can cause alterations in gene expression and epigenetic programming as well as postnatal inflammatory responses in the offspring. Insights from our own studies demonstrate epigenetic modifications of TLRs associated with exposure to intrauterine inflammation, as well as a cross talk between host epigenome and microbiome. Lastly, the gut microbiome modulates maturation of inflammatory pathways, which influences the development of preterm infants.

Summary: We present a unifying theme that preterm infant outcomes are associated with modulation of host immune and inflammatory responses, which are influenced by acute intrauterine infection, epigenetic, and microbiome factors.

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宫内炎症、表观遗传学和微生物组对早产儿健康的影响。

综述的目的：大量研究表明，微生物组可调节围产期和产后健康。本综述旨在研究宫内感染、表观基因组和微生物组对早产儿健康结果的具体影响机制：宫内感染是早产的主要原因，可导致后代基因表达和表观遗传编程的改变以及产后炎症反应。我们自己的研究表明，TLRs 的表观遗传修饰与宫内炎症暴露有关，宿主表观遗传组和微生物组之间存在交叉对话。最后，肠道微生物组调节炎症通路的成熟，从而影响早产儿的发育。摘要：我们提出了一个统一的主题，即早产儿的结局与宿主免疫和炎症反应的调节有关，而宿主免疫和炎症反应受到宫内急性感染、表观遗传和微生物组因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.