A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS.

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

E V Blinova, M A Halzova, D S Blinov

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Abstract

The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats.

Material and methods: The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury.

Results: There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ's structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn't associated with faetotoxicity and embriototoxity in experiments in rats.

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2-氨基乙磺酸镁对对乙酰氨基酚和乙醇致妊娠大鼠肝损伤的保护作用。

目的:探讨新型药物2-氨基乙磺酸镁对妊娠大鼠实验性肝炎的预防作用。材料与方法:采用对乙酰氨基酚和乙醇致肝损伤的妊娠1周大鼠为实验对象。结果:国产新化合物2-氨基乙磺酸镁(实验室名LBK-527)每日给药28 mg/kg / s，连续6 d，可限制妊娠大鼠对乙酰氨基酚或乙醇摄入引起的细胞溶解和胆汁淤滞。研究表明，同时给予LBK-527与500 mg/kg扑热息痛或10 ml/kg 40%乙醇的动物肝脏在结构上仍接近正常。该物质可防止上述毒物引起的急性中毒性肝营养不良和器官结构解体。在大鼠实验中，给予治疗剂量的LBK-527与胎儿毒性和胚胎毒性无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology

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