The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent.

IF 1.6 Q4 ONCOLOGY
International Journal of Breast Cancer Pub Date : 2018-05-16 eCollection Date: 2018-01-01 DOI:10.1155/2018/4786819
Jessica M S Jutzy, Jeffrey M Lemons, Jason J Luke, Steven J Chmura
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引用次数: 0

Abstract

Radiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic setting is evolving to harness its immune-enhancing properties. Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. The use of immunotherapeutics to promote antitumoral immunity has resulted in improved treatment responses in patients with metastatic disease and the combination of radiation therapy and immunotherapy has become an area of intense investigation. In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.

转移性乳腺癌放射治疗的演变:从局部治疗到全身用药。
放射治疗是早期和局部晚期乳腺癌的主要治疗手段,但通常只用于缓解转移性乳腺癌患者的症状性病变。随着肿瘤生物学和免疫学领域的新进展,放射治疗在转移性乳腺癌中的作用正朝着利用其免疫增强特性的方向发展。通过向肿瘤微环境释放肿瘤抗原、肿瘤 DNA 和细胞因子,辐射可增强抗肿瘤免疫反应,从而影响靶病灶和远处转移部位。使用免疫治疗药物促进抗肿瘤免疫已使转移性疾病患者的治疗反应得到改善,而放疗与免疫治疗的结合也已成为研究的热点。在本文中,我们将回顾放射治疗在转移性疾病治疗中的新作用,并讨论研究放射治疗与免疫治疗结合的科学现状和临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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