Homeostatic plasticity in neural development.

IF 4 3区生物学 Q1 DEVELOPMENTAL BIOLOGY

Neural Development Pub Date : 2018-06-01 DOI:10.1186/s13064-018-0105-x

Nai-Wen Tien, Daniel Kerschensteiner

引用次数: 79

Abstract

Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their changing connectivity, neural circuits maintain relatively constant activity levels. Neural circuits achieve functional stability by homeostatic plasticity, which equipoises intrinsic excitability and synaptic strength, balances network excitation and inhibition, and coordinates changes in circuit connectivity. Here, we review how diverse mechanisms of homeostatic plasticity stabilize activity in developing neural circuits.

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神经发育中的内稳态可塑性。

在整个生命过程中，神经回路会改变它们的连通性，尤其是在发育过程中，神经元会频繁地伸展和收缩树突和轴突，形成和消除突触。尽管它们的连通性在变化，但神经回路保持相对恒定的活动水平。神经回路通过内稳态可塑性实现功能稳定，内稳态可塑性平衡了神经网络的兴奋性和突触强度，平衡了神经网络的兴奋和抑制，协调了神经回路连通性的变化。在这里，我们回顾了动态平衡可塑性的不同机制如何稳定神经回路的活动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Development 生物-发育生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neural Development is a peer-reviewed open access, online journal, which features studies that use molecular, cellular, physiological or behavioral methods to provide novel insights into the mechanisms that underlie the formation of the nervous system. Neural Development aims to discover how the nervous system arises and acquires the abilities to sense the world and control adaptive motor output. The field includes analysis of how progenitor cells form a nervous system during embryogenesis, and how the initially formed neural circuits are shaped by experience during early postnatal life. Some studies use well-established, genetically accessible model systems, but valuable insights are also obtained from less traditional models that provide behavioral or evolutionary insights.