Prevalence of Multidrug-Resistant Tuberculosis and Associated Factors in Ethiopia: A Systematic Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2018-04-03 eCollection Date: 2018-01-01 DOI:10.1155/2018/7104921

Solomon Weldegebreal Asgedom, Mebrahtu Teweldemedhin, Hailay Gebreyesus

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引用次数: 36

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) has continued to be a challenge for tuberculosis (TB) control globally. Ethiopia is one of the countries with high MDR-TB burden.

Objective: The main purpose of this study was to determine the prevalence of MDR-TB and associated factors in Ethiopia.

Methods: A systematic review of the literatures on prevalence of MDR-TB and associated factors was conducted in the country.

Results: In our electronic search, 546 citations were depicted. Among the total 546 citations described, a total of 22 articles met eligibility criteria and were included in the review article. According to our review, the prevalence of MDR-TB ranged from 0 to 46.3%. The average mean rate of MDR-TB in Ethiopia was found to be 12.6 ± 15.9%. The overall prevalence of MDR-TB in all TB cases was estimated to be 1.4%. From a total of 3849 patients studied, 527 had MDR-TB. Previous exposure to antituberculosis treatment was the most commonly identified risk factor of MDR-TB in Ethiopia.

Conclusion: Despite relative decline in incidence of MDR-TB, the distribution and prevalence of MDR-TB continued to be a serious challenge for TB control in Ethiopia. Previous exposure to antituberculosis treatment was also the most common risk factor for MDR-TB. Therefore, strong TB and MDR-TB treatment along with tight introduction of follow-up strategies should be applied for better TB control.

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埃塞俄比亚耐多药结核病患病率及相关因素:一项系统综述。

背景:耐多药结核病(MDR-TB)一直是全球结核病控制面临的挑战。埃塞俄比亚是耐多药结核病高负担国家之一。目的:本研究的主要目的是确定埃塞俄比亚耐多药结核病的患病率及其相关因素。方法:对国内有关耐多药结核病流行及相关因素的文献进行系统综述。结果:在我们的电子检索中，描述了546条引文。在所描述的546条引文中，共有22篇文章符合资格标准，被纳入综述文章。根据我们的综述，耐多药结核病的患病率从0%到46.3%不等。埃塞俄比亚耐多药结核平均感染率为12.6±15.9%。在所有结核病例中，耐多药结核的总流行率估计为1.4%。在总共3849名被研究的患者中，527人患有耐多药结核病。在埃塞俄比亚，以前接受过抗结核治疗是最常见的耐多药结核病危险因素。结论:尽管耐多药结核病的发病率相对下降，但耐多药结核病的分布和流行仍然是埃塞俄比亚结核病控制的一个严重挑战。以前接受过抗结核治疗也是耐多药结核病最常见的危险因素。因此，应加强结核病和耐多药结核病治疗，同时严格实施后续战略，以更好地控制结核病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.