The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.

Q2 Biochemistry, Genetics and Molecular Biology

Small GTPases Pub Date : 2020-09-01 Epub Date: 2018-05-28 DOI:10.1080/21541248.2018.1463895

Fabian R Villagomez, Oscar Medina-Contreras, Jorge Francisco Cerna-Cortes, Genaro Patino-Lopez

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引用次数: 16

Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.

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致癌基因Rab35在癌症侵袭、转移和免疫逃避中的作用，特别是在白血病中。

对癌症的研究使研究人员能够描述肿瘤细胞在发育过程中获得的一些生物学特征，即所谓的“癌症特征”，但还需要更多的研究来扩大我们对癌症生物学的了解，并产生新的治疗策略。RabGTPases可能在癌症的一些特征中发挥的作用代表了有趣的研究领域，因为这些蛋白质在癌症中经常发生改变。然而，他们的参与并不为人所知。最近，Rab35被认为是一种致癌的RabGTPase，并且由于它与不同的细胞功能相关，在免疫细胞中尤为重要，Rab35可能在白血病中起作用。然而，Rab35在癌症中的作用仍然知之甚少，它在白血病中的可能的具体作用仍然未知。在这篇综述中，我们分析RabGTPases参与癌症的一般方面，特别是Rab35在白血病中的可能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small GTPases Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.10

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0.00%

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