Lower Heart Rate Variability Is Associated with Lower Pulse Pressure Amplification: Role of Obesity.

IF 7.3 Q1 PERIPHERAL VASCULAR DISEASE

Pulse Pub Date : 2018-03-01 Epub Date: 2017-09-07 DOI:10.1159/000479701

Nicola Di Daniele, Manfredi Tesauro, Alberto Mascali, Valentina Rovella, Angelo Scuteri

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引用次数: 5

Abstract

Background: Heart rate variability (HRV), pulse pressure amplification, and obesity represent risk factors for cardiovascular events. The aims of the present study are (1) to explore the impact of HRV on pulse pressure amplification and (2) to investigate whether the association between HRV and pulse pressure amplification differs in obese and lean subjects.

Methods: A total of 342 patients (age 61 ± 11 years) were enrolled. HRV was analyzed concerning both the frequency and time domain as well as concerning the HRV triangular index. Pulse pressure amplification was estimated as the ratio between brachial and carotid pulse pressure, the latter measured with SphygmoCor.

Results: Time domain HRV indices were directly correlated with pulse pressure amplification (the lower the HRV indices, the lower the pulse pressure amplification). This association was stronger in obese than in lean subjects after controlling for age and sex.

Conclusion: Larger controlled studies are needed to provide a more detailed insight into the relation between HRV and pulse pressure amplification and to determine which pathways are differentially activated in lean and obese subjects.

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低心率变异性与低脉压放大相关:肥胖的作用。

背景:心率变异性(HRV)、脉压放大和肥胖是心血管事件的危险因素。本研究的目的是:(1)探讨心率变异对脉压放大的影响;(2)探讨肥胖和瘦弱受试者中心率变异与脉压放大之间的关联是否存在差异。方法:共纳入342例患者(年龄61±11岁)。从频域、时域和三角指数两方面分析了HRV。脉压放大用肱动脉和颈动脉脉压之比来估计，颈动脉脉压用sphygmoor测量。结果:时域HRV指数与脉压放大直接相关(HRV指数越低，脉压放大越低)。在控制了年龄和性别之后，肥胖受试者的这种关联比瘦弱受试者更强。结论:需要更大规模的对照研究来提供更详细的HRV和脉压放大之间的关系，并确定哪些途径在瘦弱和肥胖受试者中被不同地激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pulse

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4.50%

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