Classification of Alzheimer's and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET.

IF 3.3 Q2 ENGINEERING, BIOMEDICAL
International Journal of Biomedical Imaging Pub Date : 2018-03-15 eCollection Date: 2018-01-01 DOI:10.1155/2018/1247430
Seyed Hossein Nozadi, Samuel Kadoury, The Alzheimer's Disease Neuroimaging Initiative
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引用次数: 0

Abstract

Early identification of dementia in the early or late stages of mild cognitive impairment (MCI) is crucial for a timely diagnosis and slowing down the progression of Alzheimer's disease (AD). Positron emission tomography (PET) is considered a highly powerful diagnostic biomarker, but few approaches investigated the efficacy of focusing on localized PET-active areas for classification purposes. In this work, we propose a pipeline using learned features from semantically labelled PET images to perform group classification. A deformable multimodal PET-MRI registration method is employed to fuse an annotated MNI template to each patient-specific PET scan, generating a fully labelled volume from which 10 common regions of interest used for AD diagnosis are extracted. The method was evaluated on 660 subjects from the ADNI database, yielding a classification accuracy of 91.2% for AD versus NC when using random forests combining features from cross-sectional and follow-up exams. A considerable improvement in the early versus late MCI classification accuracy was achieved using FDG-PET compared to the AV-45 compound, yielding a 72.5% rate. The pipeline demonstrates the potential of exploiting longitudinal multiregion PET features to improve cognitive assessment.

Abstract Image

Abstract Image

Abstract Image

从语义分割的 PET 图像对阿尔茨海默氏症和 MCI 患者进行分类:AV45 和 FDG-PET 的比较。
早期识别轻度认知障碍(MCI)早期或晚期的痴呆症对于及时诊断和延缓阿尔茨海默病(AD)的进展至关重要。正电子发射断层扫描(PET)被认为是一种功能强大的诊断生物标志物,但很少有方法研究过将重点放在局部 PET 活跃区域进行分类的有效性。在这项工作中,我们提出了一种利用从语义标记的 PET 图像中学习到的特征来进行群体分类的方法。我们采用了一种可变形的多模态 PET-MRI 配准方法,将注释过的 MNI 模板融合到每个患者特定的 PET 扫描中,生成一个完全标记的体积,从中提取出 10 个用于诊断 AD 的常见感兴趣区。该方法在 ADNI 数据库的 660 名受试者身上进行了评估,当使用结合横断面和随访检查特征的随机森林时,AD 与 NC 的分类准确率为 91.2%。使用 FDG-PET 与 AV-45 复合物相比,早期 MCI 与晚期 MCI 的分类准确率有了显著提高,达到了 72.5%。该管道展示了利用纵向多区域 PET 特征改进认知评估的潜力。
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来源期刊
CiteScore
12.00
自引率
0.00%
发文量
11
审稿时长
20 weeks
期刊介绍: The International Journal of Biomedical Imaging is managed by a board of editors comprising internationally renowned active researchers. The journal is freely accessible online and also offered for purchase in print format. It employs a web-based review system to ensure swift turnaround times while maintaining high standards. In addition to regular issues, special issues are organized by guest editors. The subject areas covered include (but are not limited to): Digital radiography and tomosynthesis X-ray computed tomography (CT) Magnetic resonance imaging (MRI) Single photon emission computed tomography (SPECT) Positron emission tomography (PET) Ultrasound imaging Diffuse optical tomography, coherence, fluorescence, bioluminescence tomography, impedance tomography Neutron imaging for biomedical applications Magnetic and optical spectroscopy, and optical biopsy Optical, electron, scanning tunneling/atomic force microscopy Small animal imaging Functional, cellular, and molecular imaging Imaging assays for screening and molecular analysis Microarray image analysis and bioinformatics Emerging biomedical imaging techniques Imaging modality fusion Biomedical imaging instrumentation Biomedical image processing, pattern recognition, and analysis Biomedical image visualization, compression, transmission, and storage Imaging and modeling related to systems biology and systems biomedicine Applied mathematics, applied physics, and chemistry related to biomedical imaging Grid-enabling technology for biomedical imaging and informatics
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