[Thyroid and aging: the present state of art].

Przeglad lekarski Pub Date : 2017-01-01
Robert Krysiak, Karolina Kowalcze, Agnieszka Kędzia, Bogusław Okopień
{"title":"[Thyroid and aging: the present state of art].","authors":"Robert Krysiak,&nbsp;Karolina Kowalcze,&nbsp;Agnieszka Kędzia,&nbsp;Bogusław Okopień","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is associated with important\nchanges in thyroid hormone secretion,\nmetabolism, and action. It\nremains unclear, however, whether\naltered activity of the hypothamic-pituitary-\nthyroid axis represents physiologic\nchanges in thyroid function or\nwhether they are secondary to thyroid\ndysfunction. The prevalence of\nthyroid disorders increases with age,\nbut because some thyroid-associated\nsymptoms are similar to symptoms\nof the aging process, these disorders\nare relatively rarely diagnosed. On the\nother hand, because of the possible\npresence of chronic, non-thyroidal\nillnesses or pharmacotherapy, diagnosis\nof thyroid disorders in older\npopulations is often much more challenging\nthan in young people. Progress\nmade in better understanding\nof thyroid disorders in older people\nhas thrown a new light on the management\nof patients with these disorders,\nthe clinical picture of which is\noften atypical. Therefore, physicians\nneed a high index of suspicion to detect\nthyroid dysfunction in an older\nperson with multiple comorbidities\nand chronic polypharmacy. The purpose\nof this article is to review the\npresent state of knowledge on the\nage-related changes in hypothalamicpituitary-\nthyroid axis activity and to\ndiscuss the clinical course, diagnosis\nand treatment of thyroid disorders in\nthe elderly.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aging is associated with important changes in thyroid hormone secretion, metabolism, and action. It remains unclear, however, whether altered activity of the hypothamic-pituitary- thyroid axis represents physiologic changes in thyroid function or whether they are secondary to thyroid dysfunction. The prevalence of thyroid disorders increases with age, but because some thyroid-associated symptoms are similar to symptoms of the aging process, these disorders are relatively rarely diagnosed. On the other hand, because of the possible presence of chronic, non-thyroidal illnesses or pharmacotherapy, diagnosis of thyroid disorders in older populations is often much more challenging than in young people. Progress made in better understanding of thyroid disorders in older people has thrown a new light on the management of patients with these disorders, the clinical picture of which is often atypical. Therefore, physicians need a high index of suspicion to detect thyroid dysfunction in an older person with multiple comorbidities and chronic polypharmacy. The purpose of this article is to review the present state of knowledge on the age-related changes in hypothalamicpituitary- thyroid axis activity and to discuss the clinical course, diagnosis and treatment of thyroid disorders in the elderly.

[甲状腺与衰老:目前的研究现状]。
衰老与甲状腺激素分泌、代谢和作用的重要变化有关。然而,尚不清楚的是,下丘脑-垂体-甲状腺轴活性的改变是否代表甲状腺功能的生理改变,还是继发于甲状腺功能障碍。甲状腺疾病的患病率随着年龄的增长而增加,但由于一些甲状腺相关症状与衰老过程的症状相似,这些疾病相对很少被诊断出来。另一方面,由于可能存在慢性、非甲状腺疾病或药物治疗,老年人甲状腺疾病的诊断往往比年轻人更具挑战性。更好地了解老年人甲状腺疾病的进展为这些疾病患者的管理带来了新的曙光,这些疾病的临床表现通常是非典型的。因此,医生需要高度的怀疑指数来检测患有多种合并症和慢性多种药物的老年人的甲状腺功能障碍。本文旨在综述与年龄相关的下丘脑-垂体-甲状腺轴活动变化的研究现状,并对老年人甲状腺疾病的临床病程、诊断和治疗进行探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信