Robert Krysiak, Karolina Kowalcze, Agnieszka Kędzia, Bogusław Okopień
{"title":"[Thyroid and aging: the present state of art].","authors":"Robert Krysiak, Karolina Kowalcze, Agnieszka Kędzia, Bogusław Okopień","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is associated with important\nchanges in thyroid hormone secretion,\nmetabolism, and action. It\nremains unclear, however, whether\naltered activity of the hypothamic-pituitary-\nthyroid axis represents physiologic\nchanges in thyroid function or\nwhether they are secondary to thyroid\ndysfunction. The prevalence of\nthyroid disorders increases with age,\nbut because some thyroid-associated\nsymptoms are similar to symptoms\nof the aging process, these disorders\nare relatively rarely diagnosed. On the\nother hand, because of the possible\npresence of chronic, non-thyroidal\nillnesses or pharmacotherapy, diagnosis\nof thyroid disorders in older\npopulations is often much more challenging\nthan in young people. Progress\nmade in better understanding\nof thyroid disorders in older people\nhas thrown a new light on the management\nof patients with these disorders,\nthe clinical picture of which is\noften atypical. Therefore, physicians\nneed a high index of suspicion to detect\nthyroid dysfunction in an older\nperson with multiple comorbidities\nand chronic polypharmacy. The purpose\nof this article is to review the\npresent state of knowledge on the\nage-related changes in hypothalamicpituitary-\nthyroid axis activity and to\ndiscuss the clinical course, diagnosis\nand treatment of thyroid disorders in\nthe elderly.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aging is associated with important
changes in thyroid hormone secretion,
metabolism, and action. It
remains unclear, however, whether
altered activity of the hypothamic-pituitary-
thyroid axis represents physiologic
changes in thyroid function or
whether they are secondary to thyroid
dysfunction. The prevalence of
thyroid disorders increases with age,
but because some thyroid-associated
symptoms are similar to symptoms
of the aging process, these disorders
are relatively rarely diagnosed. On the
other hand, because of the possible
presence of chronic, non-thyroidal
illnesses or pharmacotherapy, diagnosis
of thyroid disorders in older
populations is often much more challenging
than in young people. Progress
made in better understanding
of thyroid disorders in older people
has thrown a new light on the management
of patients with these disorders,
the clinical picture of which is
often atypical. Therefore, physicians
need a high index of suspicion to detect
thyroid dysfunction in an older
person with multiple comorbidities
and chronic polypharmacy. The purpose
of this article is to review the
present state of knowledge on the
age-related changes in hypothalamicpituitary-
thyroid axis activity and to
discuss the clinical course, diagnosis
and treatment of thyroid disorders in
the elderly.