Intense Pulsed Light Applied Directly on Eyelids Combined with Meibomian Gland Expression to Treat Meibomian Gland Dysfunction.

Q2 Medicine

Photomedicine and laser surgery Pub Date : 2018-06-01 Epub Date: 2018-04-24 DOI:10.1089/pho.2017.4402

Bei Rong, Yun Tang, Ping Tu, Ruixing Liu, Jing Qiao, Wenjing Song, Rolando Toyos, Xiaoming Yan

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引用次数: 70

Abstract

Objective: To determine the efficacy and safety of intense pulsed light (IPL) applied directly on the eyelids and meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD).

Background: IPL application on the periocular skin effectively improves meibomian gland secretion and tear film break-up time (TBUT) in patients with MGD/dry eye.

Methods: This prospective, randomized, double-masked, controlled study involved 44 patients. One eye was randomly selected for IPL treatment; the other served as a control. Study eyes received three IPL treatments at 4-week intervals; IPL was applied directly on the eyelids, and the eye was protected with a Jaeger lid plate. Control eyes received sham IPL treatments. Both eyes received MGX and artificial tears. Meibomian gland yielding secretion score (MGYSS), TBUT, Standard Patient Evaluation of Eye Dryness (SPEED), cornea fluorescein staining (CFS), meibography, best corrected visual acuity (BCVA), intraocular pressure (IOP), and fundus examination were performed.

Results: Compared to the baseline, MGYSS, TBUT, and SPEED and CFS scores improved in the study eyes, while only SPEED and CFS scores improved in the control eyes (p < 0.001 for all). Changes in MGYSS and TBUT were higher in the study eyes than in the control eyes (p < 0.05), but changes in SPEED and CFS scores were similar (p > 0.05). BCVA and IOP improved in both the study and control eyes (p < 0.05). Five patients experienced mild pain and burning during IPL treatment. One patient suffered partial eyelash loss.

Conclusions: IPL combined with MGX safely and effectively treated MGD.

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强脉冲光直接照射眼睑联合睑板腺表达治疗睑板腺功能障碍。

目的:探讨强脉冲光(IPL)直接照射眼睑及睑板腺表达(MGX)治疗睑板腺功能障碍(MGD)的疗效和安全性。背景:IPL应用于眼周皮肤可有效改善MGD/干眼症患者睑板腺分泌和泪膜破裂时间(TBUT)。方法:这项前瞻性、随机、双盲、对照研究纳入44例患者。随机选择1眼进行IPL治疗;另一组作为对照。研究眼每隔4周接受3次IPL治疗;将IPL直接涂抹在眼睑上，并用积家盖板保护眼睛。对照眼接受假IPL治疗。双眼均接受了MGX和人工泪液治疗。进行睑板腺分泌评分(MGYSS)、TBUT、标准患者眼干评价(SPEED)、角膜荧光素染色(CFS)、睑板计数、最佳矫正视力(BCVA)、眼压(IOP)、眼底检查。结果:与基线相比，研究眼MGYSS、TBUT、SPEED和CFS评分均有改善，而对照眼仅SPEED和CFS评分有改善(p 0.05)。研究和对照眼的BCVA和IOP均有改善(p)。结论:IPL联合MGX治疗MGD安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photomedicine and laser surgery 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Photobiomodulation, Photomedicine, and Laser Surgery (formerly Photomedicine and Laser Surgery) is the essential journal for cutting-edge advances and research in phototherapy, low-level laser therapy (LLLT), and laser medicine and surgery. The Journal delivers basic and clinical findings and procedures to improve the knowledge and application of these techniques in medicine.