[Comparison of the prevalence of chronic kidney disease in patients of the Emergency Department of the Regional Hospital in Kielce based on GFR estimation according abbreviated MDRD formula or CKD-EPI equation].

Przeglad lekarski Pub Date : 2016-01-01

Pawel Wróbel, Władysław Sułowicz

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Abstract

Introduction: Glomerular filtration rate plays a key role in the diagnosis of chronic kidney disease (CKD). In everyday practice GFR is estimated using equations based on serum creatinine. Commonly used abbreviated MDRD formula is not very precise in patients with mildly impaired renal function, underestimating eGFR when greater than 60 ml/min/1.73 m2. CKD-EPI formula, recommended by KDIGO, might be a good alternative in this situation. The aim of the study was to compare the prevalence of consecutive stages of CKD in the group of patients from Emergency Department having calculated eGFR according MDRD and CKD-EPI formulas

Materials and methods: The retrospective study was performed in the group of 1,452 patients (762 women and 690 men aged 57.4 years ± 19.8 years). Estimated GFR (eGFR) was calculated based on MDRD and CKD-EPI formulas and the obtained results were analyzed according patients location in the consecutive group of CKD, used formulas, sex and age.

Results: The mean values of eGFR for both formulas were similar and for MDRD was 68.6 ± 22.3 ml/min/ 1.73 m2 while for CKD-EPI 69.18 ± 24.4 ml/ min/1.73 m2. The highest differences were observed in the early stages of CKD where the calculation of eGFR based on CKD-EPI vs MDRD formula gives an increase of population in stage G1 of CKD by 5.7% (342 vs 241 persons) and reduction by 7.8% (625 vs 737) in the stage G2.

Conclusions: Both formulas have the similar value in the estimation of CKD. The differences concerning mainly G1 and G2 stages.

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[基于缩写MDRD公式与CKD-EPI方程GFR估算的Kielce地区医院急诊科慢性肾脏疾病患病率比较]。

肾小球滤过率在慢性肾脏疾病(CKD)的诊断中起着关键作用。在日常实践中，GFR是使用基于血清肌酐的方程来估计的。对于轻度肾功能受损的患者，常用的缩写MDRDformula不是很精确，当eGFR大于60ml /min/1.73 m2时低估了eGFR。在这种情况下，KDIGO推荐的CKD-EPI配方可能是一个很好的选择。本研究的目的是比较急诊科根据MDRD和CKD- epi公式计算eGFR的患者组连续CKD的患病率。材料和方法:回顾性研究在1452例患者中进行(762例女性和690例男性，年龄57.4岁±19.8岁)。估算GFR (eGFR)基于MDRD和CKD- epiformula计算，并根据患者在连续CKD组中的位置、使用的formula、性别和年龄进行分析。结果:两方egfr均值相近，forMDRD为68.6±22.3 ml/min/1.73 m2, CKD-EPI为69.18±24.4 ml/min/1.73 m2。在CKD的早期阶段观察到最大的差异，基于CKD- epi与MDRD公式计算的egfr显示，CKD G1期人群增加5.7%(342人对241人)，G2期减少7.8%(625人对737人)。结论:两种公式对CKD的估计价值相近。差异主要集中在G1期和G2期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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