Matthew Q Clark, Aref Arzan Zarin, Arnaldo Carreira-Rosario, Chris Q Doe
{"title":"Neural circuits driving larval locomotion in Drosophila.","authors":"Matthew Q Clark, Aref Arzan Zarin, Arnaldo Carreira-Rosario, Chris Q Doe","doi":"10.1186/s13064-018-0103-z","DOIUrl":null,"url":null,"abstract":"<p><p>More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.</p>","PeriodicalId":49764,"journal":{"name":"Neural Development","volume":"13 1","pages":"6"},"PeriodicalIF":4.0000,"publicationDate":"2018-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907184/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neural Development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s13064-018-0103-z","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.
期刊介绍：
Neural Development is a peer-reviewed open access, online journal, which features studies that use molecular, cellular, physiological or behavioral methods to provide novel insights into the mechanisms that underlie the formation of the nervous system.
Neural Development aims to discover how the nervous system arises and acquires the abilities to sense the world and control adaptive motor output. The field includes analysis of how progenitor cells form a nervous system during embryogenesis, and how the initially formed neural circuits are shaped by experience during early postnatal life. Some studies use well-established, genetically accessible model systems, but valuable insights are also obtained from less traditional models that provide behavioral or evolutionary insights.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
