A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Gordana Kovacevic, Dejan Stevanovic, Dragana Bogicevic, Dimitrije Nikolic, Slavica Ostojic, Biljana Vucetic Tadic, Blažo Nikolic, Ivana Bosiocic, Nikola Ivancevic, Kristina Jovanovic, Janko Samardzic, Jasna Jancic
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引用次数: 7

Abstract

Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (RCADS). PedMIDAS scores significantly decreased from baseline to end-point (F(df, dferror) = 11.10 (1.63, 50.49), p<0.001), as well as anxiety (F(df, dferror) = 8.95 (1.64, 50.67), p = 0.001) and depressive symptoms (F(df, dferror) = 8.91 (1.59, 49.29), p = 0.001). Considering the KIDSCREEN-27, scores for physical and psychological well-being and social support domain significantly increased from baseline to end-point (p≤0.01). After 6 months of magnesium prophylaxis, disability due to migraine significantly decreased, whereas physical and psychosocial well-being improved. Children also reported fewer anxiety and depressive symptoms. More follow-up and randomized controlled clinical trials are needed to propose clinical recommendations for magnesium prophylaxis in pediatric migraine.

镁预防治疗对儿童偏头痛患者残疾、生活质量、抑郁和焦虑症状的6个月随访
镁常用于儿童偏头痛预防。本研究的目的是评估儿童偏头痛患者6个月镁预防治疗后残疾水平、生活质量(QOL)、焦虑和抑郁症状的改变程度。这是一项随访研究,研究对象为34名7-17岁的儿童,偏头痛患者接受口服镁治疗。使用儿童偏头痛残疾评估工具(PedMIDAS)评估偏头痛所致残疾,使用KIDSCREEN-27评估生活质量,使用修订儿童焦虑和抑郁量表(RCADS)评估焦虑和抑郁症状。PedMIDAS评分从基线到终点显著下降(F(df, difference) = 11.10 (1.63, 50.49), perror) = 8.95 (1.64, 50.67), p = 0.001),抑郁症状(F(df, difference) = 8.91 (1.59, 49.29), p = 0.001)。考虑到KIDSCREEN-27,生理、心理健康和社会支持领域的得分从基线到终点显著增加(p≤0.01)。镁预防治疗6个月后,偏头痛导致的残疾显著减少,而身体和心理健康得到改善。儿童的焦虑和抑郁症状也较少。需要更多的随访和随机对照临床试验来提出镁预防儿童偏头痛的临床建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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