Impact of body weight on clinical symptoms and endoscopic changes in patients with gastroesophageal reflux disease.

Przeglad lekarski Pub Date : 2016-01-01

Malgorzata Krakowska-Stasiak, Dorota Cibor, Kinga Sałapa, Danuta Owczarek, Tomasz Mach

{"title":"Impact of body weight on clinical symptoms and endoscopic changes in patients with gastroesophageal reflux disease.","authors":"Malgorzata Krakowska-Stasiak, Dorota Cibor, Kinga Sałapa, Danuta Owczarek, Tomasz Mach","doi":"","DOIUrl":null,"url":null,"abstract":"Introduction: Gastroesophageal\nreflux disease (GERD) is connected\nwith body mass index (BMI) according\nto some recent studies. However, the\nlink between overweight and severity\nof GERD symptoms is still unclear.Objectives: The aim of our study\nis to assess the influence of BMI on\nclinical presentation and occurrence\nof inflammatory changes in the esophagus\nin patients with GERD.Material and methods: 121 clinically\ndiagnosed GERD patients: 66 males\n(54.5%) and 55 females (45.5%), aged\n19 – 89 years were involved in the\nstudy. After the detailed anamnesis\nBMI was counted and gastroscopy\nwas performed. All individuals who\nagreed for upper endoscopy were\ndivided into three groups. 42 patients\n(34.7%) were classified as Non-Erosive\nReflux Disease (NERD), 53 patients\n(43.8%) were diagnosed with Erosive\nEsophagitis (EE), 11 patients (9.1%)\nwith Barrett’s esophagus (BE). Among\nEE group 34 patients were diagnosed\nwith grade A of esophagitis according\nto Los Angeles scale, 17 with grade B,\n2 with grade C and none with grade D.\nThe differences between groups were\nassessed using statistical analysis.Results: The mean age of patients\nwas 50.2±12.9 years and the mean\nBMI was 25.5±4.2 kg/m2. Patients with\nBE were older (61.2±12.0 years) than\nNERD (48.5±13.6 years); (p=0.028) and\nEE (50.4±11.4 years); (p=0.008). BE had\nhigher BMI (27.0±4.4 kg/m2) as compared\nto NERD (24.0±3.3 kg/m2); (p=0.022)\nand EE (24.4±3.1 kg/m2); (p=0.048). Hiatal\nhernia was more frequent in EE and\nBE (79.2% and 90.9%, respectively) as\ncompared to NERD (45.2%); (p<0.001).\nPatients EE and BE more frequently\ncomplained to heartburn (84.9% and\n72.7%, respectively) than patients with\nno mucosal injury (42.9%); (p<0.001).\nSleeping problems were encountered\nby patients with higher levels of BMI.Conclusion: This study demonstrates\nthat overweight predispose to\nesophageal inflammation and increase\nthe frequency of heartburn and sleep\nproblems in GERD patients.","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is connected with body mass index (BMI) according to some recent studies. However, the link between overweight and severity of GERD symptoms is still unclear.

Objectives: The aim of our study is to assess the influence of BMI on clinical presentation and occurrence of inflammatory changes in the esophagus in patients with GERD.

Material and methods: 121 clinically diagnosed GERD patients: 66 males (54.5%) and 55 females (45.5%), aged 19 – 89 years were involved in the study. After the detailed anamnesis BMI was counted and gastroscopy was performed. All individuals who agreed for upper endoscopy were divided into three groups. 42 patients (34.7%) were classified as Non-Erosive Reflux Disease (NERD), 53 patients (43.8%) were diagnosed with Erosive Esophagitis (EE), 11 patients (9.1%) with Barrett’s esophagus (BE). Among EE group 34 patients were diagnosed with grade A of esophagitis according to Los Angeles scale, 17 with grade B, 2 with grade C and none with grade D. The differences between groups were assessed using statistical analysis.

Results: The mean age of patients was 50.2±12.9 years and the mean BMI was 25.5±4.2 kg/m2. Patients with BE were older (61.2±12.0 years) than NERD (48.5±13.6 years); (p=0.028) and EE (50.4±11.4 years); (p=0.008). BE had higher BMI (27.0±4.4 kg/m2) as compared to NERD (24.0±3.3 kg/m2); (p=0.022) and EE (24.4±3.1 kg/m2); (p=0.048). Hiatal hernia was more frequent in EE and BE (79.2% and 90.9%, respectively) as compared to NERD (45.2%); (p<0.001). Patients EE and BE more frequently complained to heartburn (84.9% and 72.7%, respectively) than patients with no mucosal injury (42.9%); (p<0.001). Sleeping problems were encountered by patients with higher levels of BMI.

Conclusion: This study demonstrates that overweight predispose to esophageal inflammation and increase the frequency of heartburn and sleep problems in GERD patients.

本刊更多论文

体重对胃食管反流病患者临床症状及内镜改变的影响

最近的一些研究表明胃食管反流病(GERD)与身体质量指数(BMI)有关。然而，超重与反流症状严重程度之间的联系尚不清楚。目的:我们研究的目的是评估BMI对食管反流患者的临床表现和炎症改变发生的影响。材料与方法:121例临床诊断为胃食管反流的患者:男性66例(54.5%)，女性55例(45.5%)，年龄19 ~ 89岁。详细回忆后计算bmi并行胃镜检查。所有同意接受上颌内窥镜检查的人被分为三组。非糜烂性食管炎(NERD) 42例(34.7%)，糜烂性食管炎(EE) 53例(43.8%)，Barrett食管(BE) 11例(9.1%)。根据洛杉矶分级法，34例患者被诊断为A级食管炎，17例为B级，2例为C级，无患者被诊断为d级。组间比较采用统计学分析。结果:患者平均年龄为50.2±12.9岁，平均bmi为25.5±4.2 kg/m2。be患者年龄(61.2±12.0岁)大于annerd(48.5±13.6岁);(p=0.028)， dee(50.4±11.4岁);(p = 0.008)。BE组BMI(27.0±4.4 kg/m2)高于NERD组(24.0±3.3 kg/m2);(p=0.022)和EE(24.4±3.1 kg/m2);(p = 0.048)。相比于NERD患者(45.2%)，EE和be患者的裂孔疝发生率更高(分别为79.2%和90.9%);结论:本研究表明，超重易导致食管炎症，并增加胃食管反流患者发生胃灼热和睡眠问题的频率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Przeglad lekarski

自引率

0.00%

发文量