Bleeding and asymptomatic overdose in patients under Vitamin K antagonist therapy: Frequency and risk factors

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Egyptian Heart Journal Pub Date : 2018-03-01 DOI:10.1016/j.ehj.2018.01.001

F. Ben Mbarka, K. Ben Jeddou, E. Allouche, I. Boukhris, N. Khalfallah, H. Baccar, Z. Ouahchi

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引用次数: 3

Abstract

Background

Vitamin K antagonists are widely used in the treatment and prevention of thromboembolic disease. However, these drugs can cause serious side effects, especially bleeding. This study aims to evaluate frequency and risk factors of both bleeding and asymptomatic overdose in North African patients undergoing Vitamin K antagonist therapy.

Methods

We performed a cross-sectional study in patients undergoing Vitamin K antagonist therapy. A statistical analysis has been conducted to identify overdose and bleeding risk factors by using chi-square test (p < .05).

Results

One hundred and eleven patients were included. We recorded 14 cases of bleeding and 26 cases of asymptomatic overdose. Advanced age, poor adherence, concomitant use of paracetamol and history of previous bleeding are significant risk factors of over-anticoagulation. An INR value over 6 at admission, a high therapeutic target range for INR, concomitant use of acetylsalicylic acid, lack of information on overdose signs and measures to be taken in case of bleeding were identified as risk factors for bleeding.

Conclusion

Most of the risk factors identified in our study seem to be related to patients lack of information and education. These results highlight the importance of creating a therapeutic patient education program.

查看原文本刊更多论文

维生素K拮抗剂治疗患者出血和无症状过量:频率和危险因素

维生素K拮抗剂广泛应用于血栓栓塞性疾病的治疗和预防。然而，这些药物会引起严重的副作用，尤其是出血。本研究旨在评估北非接受维生素K拮抗剂治疗的患者出血和无症状过量的频率和危险因素。方法我们对接受维生素K拮抗剂治疗的患者进行了横断面研究。采用卡方检验对过量用药和出血危险因素进行统计分析(p < .05)。结果共纳入111例患者。我们记录了14例出血和26例无症状用药过量。高龄、依从性差、同时使用扑热息痛和既往出血史是过度抗凝的重要危险因素。入院时INR值超过6,INR的治疗目标范围高，同时使用乙酰水杨酸，缺乏关于过量体征的信息以及出血时应采取的措施被确定为出血的危险因素。结论在我们的研究中发现的大多数危险因素似乎与患者缺乏信息和教育有关。这些结果强调了建立治疗性患者教育计划的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Egyptian Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Egyptian Heart Journal is the official journal of the Egyptian Society of Cardiology. It is an international journal that publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies and translational investigations. The journal publishes research, review articles, case reports and commentary articles, as well as editorials interpreting and commenting on the research presented. In addition, it provides a forum for the exchange of information on all aspects of cardiovascular medicine, including educational issues.