The early development of germ cells in chicken.

Young Min Kim, Jae Yong Han
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引用次数: 30

Abstract

Primordial germ cells (PGCs) are the founder cells for mature gametes, the vehicles by which individuals transmit genetic and epigenetic information to later generations. Since the 19th century, avian species (chickens in particular) have been widely used for germ cell research. Previous studies have used chicken PGCs for a variety of research applications, including as a model for studies focusing on germline development. Other applications of chicken PGCs, including conservation efforts for avian species and methods of producing transgenic birds, have further reinforced the importance of these cells. However, much remains to be revealed about the origin and role of PGCs during their development in the chicken. Here, we provide a comprehensive review of chicken PGCs, focusing in particular upon their initial profiles and physiological changes during development as regulated by environmental factors and/or intrinsic mechanisms. We also emphasise sex-dependent differences in PGC development after settlement within the gonads, as well as future applications for avian PGCs.

鸡生殖细胞的早期发育。
原始生殖细胞(PGCs)是成熟配子的创始细胞,是个体将遗传和表观遗传信息传递给后代的载体。自19世纪以来,鸟类(特别是鸡)已被广泛用于生殖细胞研究。以前的研究已经将鸡PGCs用于各种研究应用,包括作为关注种系发育的研究模型。鸡PGCs的其他应用,包括鸟类物种的保护工作和生产转基因鸟类的方法,进一步加强了这些细胞的重要性。然而,在鸡的发育过程中,PGCs的起源和作用仍有待揭示。在此,我们对鸡PGCs进行了全面的综述,特别关注它们在环境因素和/或内在机制调节下的初始概况和发育过程中的生理变化。我们还强调了PGC在性腺内定居后发育的性别依赖差异,以及鸟类PGC的未来应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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