Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats.

V M Ruvin Kumara, Marianne Wessling-Resnick
{"title":"Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats.","authors":"V M Ruvin Kumara,&nbsp;Marianne Wessling-Resnick","doi":"10.4236/jbbs.2012.22020","DOIUrl":null,"url":null,"abstract":"<p><p>Chronically high occupational exposure to airborne metals like iron can impair olfactory function, but little is known about how low iron status modifies olfactory behavior. To investigate the influence of body iron status, weanling rats were fed a diet with low iron content (4 - 7 ppm) to induce iron deficiency anemia and olfactory behavior was compared to control rats fed an isocaloric diet sufficient in iron (210 - 220 ppm). Iron-deficient rats had prolonged exploratory time for attractive odorants in behavioral olfactory habituation/dis-habituation tests, olfactory preference tests and olfactory sensitivity tests compared with control rats. No significant differences were observed for aversive odorants between the two groups. These findings suggest that iron-dependent functions may be involved in controlling and processing of olfactory signal transduction via self and lateral inhibition such that odorant signal remains stronger for longer times prolonging exploratory activity on attractive odorants in the behavioral tests. These findings establish that iron deficiency can modify olfactory behavior.</p>","PeriodicalId":15186,"journal":{"name":"Journal of Behavioral and Brain Science","volume":"2 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839520/pdf/nihms898265.pdf","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Behavioral and Brain Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/jbbs.2012.22020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14

Abstract

Chronically high occupational exposure to airborne metals like iron can impair olfactory function, but little is known about how low iron status modifies olfactory behavior. To investigate the influence of body iron status, weanling rats were fed a diet with low iron content (4 - 7 ppm) to induce iron deficiency anemia and olfactory behavior was compared to control rats fed an isocaloric diet sufficient in iron (210 - 220 ppm). Iron-deficient rats had prolonged exploratory time for attractive odorants in behavioral olfactory habituation/dis-habituation tests, olfactory preference tests and olfactory sensitivity tests compared with control rats. No significant differences were observed for aversive odorants between the two groups. These findings suggest that iron-dependent functions may be involved in controlling and processing of olfactory signal transduction via self and lateral inhibition such that odorant signal remains stronger for longer times prolonging exploratory activity on attractive odorants in the behavioral tests. These findings establish that iron deficiency can modify olfactory behavior.

缺铁对断奶大鼠嗅觉行为的影响。
长期接触空气中的铁等金属会损害嗅觉功能,但人们对低铁状态如何改变嗅觉行为知之甚少。为了研究机体铁状态对断奶大鼠的影响,研究人员给断奶大鼠喂食低铁含量(4 - 7ppm)的饲料以诱导缺铁性贫血,并将其嗅觉行为与喂食含铁量(210 - 220 ppm)等热量饲料的对照组大鼠进行比较。缺铁大鼠在行为嗅觉适应/不适应测试、嗅觉偏好测试和嗅觉敏感性测试中对吸引气味的探索时间比对照大鼠长。在两组之间没有观察到显著差异的厌恶气味。这些发现表明,铁依赖功能可能通过自我和侧抑制参与嗅觉信号转导的控制和处理,从而使气味信号在更长时间内保持更强,从而延长了行为测试中对吸引气味的探索活动。这些发现证实缺铁可以改变嗅觉行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信