[The effect of 3,5-dicarbomethoxyphenylbiguanide on the activity of antioxidant enzymes].

O A Safonova, T N Popova, E D Krylskiy, A A Agarkov, K K Shulgin, E M Kirilova, E S Tanygina
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引用次数: 0

Abstract

The effect of 3,5-dicarbomethoxyphenylbiguanide, which was selected with the Prediction of Activity Spectra of Substances (PASS) computer program, on the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase in the heart and the blood serum of rats with experimental rheumatoid arthritis was investigated. The studied parameters changed towards control values when the tested compound was injected in animals with the pathology. These results can be explained by the cardioprotective and antioxidant activity of the compound. The data obtained during the study may be used for the development of new preventive and therapeutic agents for the treatment of the rheumatoid arthritis.

[3,5-二碳甲氧基苯基双胍对抗氧化酶活性的影响]。
采用物质活性谱预测(PASS)程序筛选3,5-二甲氧基苯基双胍对实验性类风湿关节炎大鼠心脏及血清超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽转移酶活性的影响。当将所试化合物注射到病理动物体内时,所研究的参数向控制值改变。这些结果可以用化合物的心脏保护和抗氧化活性来解释。本研究获得的数据可用于开发新的类风湿关节炎的预防和治疗药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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