Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2018-02-05 eCollection Date: 2018-12-01 DOI:10.1186/s40709-018-0075-5

Umesh Chandra Halder

引用次数: 5

Abstract

Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients' death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect.

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骨髓干细胞破坏循环HIV:一种假设的治疗策略。

人类免疫缺陷病毒(HIV)仍然对人类的生命构成神秘的威胁。这种病毒已经掌握了绕过抗逆转录病毒治疗导致患者死亡的方法。传播的病毒对疾病的结果是显著的。这一假说提出了一种利用受体整合造血、红细胞和红细胞的治疗策略。在这里，HIV特异性受体捕获进入红细胞细胞质的循环病毒并形成无活性整合复合体。该模型描述了简单、有效地清除循环中的艾滋病毒而没有任何副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.