H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries.
M Ramsay, N Crowther, E Tambo, G Agongo, V Baloyi, S Dikotope, X Gómez-Olivé, N Jaff, H Sorgho, R Wagner, C Khayeka-Wandabwa, A Choudhury, S Hazelhurst, K Kahn, Z Lombard, F Mukomana, C Soo, H Soodyall, A Wade, S Afolabi, I Agorinya, L Amenga-Etego, S A Ali, J D Bognini, R P Boua, C Debpuur, S Diallo, E Fato, A Kazienga, S Z Konkobo, P M Kouraogo, F Mashinya, L Micklesfield, S Nakanabo-Diallo, B Njamwea, E Nonterah, S Ouedraogo, V Pillay, A M Somande, P Tindana, R Twine, M Alberts, C Kyobutungi, S A Norris, A R Oduro, H Tinto, S Tollman, O Sankoh
{"title":"H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries.","authors":"M Ramsay, N Crowther, E Tambo, G Agongo, V Baloyi, S Dikotope, X Gómez-Olivé, N Jaff, H Sorgho, R Wagner, C Khayeka-Wandabwa, A Choudhury, S Hazelhurst, K Kahn, Z Lombard, F Mukomana, C Soo, H Soodyall, A Wade, S Afolabi, I Agorinya, L Amenga-Etego, S A Ali, J D Bognini, R P Boua, C Debpuur, S Diallo, E Fato, A Kazienga, S Z Konkobo, P M Kouraogo, F Mashinya, L Micklesfield, S Nakanabo-Diallo, B Njamwea, E Nonterah, S Ouedraogo, V Pillay, A M Somande, P Tindana, R Twine, M Alberts, C Kyobutungi, S A Norris, A R Oduro, H Tinto, S Tollman, O Sankoh","doi":"10.1017/gheg.2016.17","DOIUrl":null,"url":null,"abstract":"<p><p>Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic and environmental factors that influence body composition, body fat distribution and CMD risk, with the aim to provide insights towards effective treatment and intervention strategies. It provides a research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya and South Africa. Following a process that involved community engagement, training of project staff and participant informed consent, participants were administered detailed questionnaires, anthropometric measurements were taken and biospecimens collected. This generated a wealth of demographic, health history, environmental, behavioural and biomarker data. The H3Africa SNP array will be used for genome-wide association studies. AWI-Gen is building capacity to perform large epidemiological, genomic and epigenomic studies across several African counties and strives to become a valuable resource for research collaborations in Africa.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.17","citationCount":"90","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/gheg.2016.17","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 90
Abstract
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic and environmental factors that influence body composition, body fat distribution and CMD risk, with the aim to provide insights towards effective treatment and intervention strategies. It provides a research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya and South Africa. Following a process that involved community engagement, training of project staff and participant informed consent, participants were administered detailed questionnaires, anthropometric measurements were taken and biospecimens collected. This generated a wealth of demographic, health history, environmental, behavioural and biomarker data. The H3Africa SNP array will be used for genome-wide association studies. AWI-Gen is building capacity to perform large epidemiological, genomic and epigenomic studies across several African counties and strives to become a valuable resource for research collaborations in Africa.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
