The toxicity of vanadium on gastrointestinal, urinary and reproductive system, and its influence on fertility and fetuses malformations.

Aleksandra Wilk, Dagmara Szypulska-Koziarska, Barbara Wiszniewska
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引用次数: 59

Abstract

Vanadium is a transition metal that has a unique and beneficial effect on both humans and animals. For many years, studies have suggested that vanadium is an essential trace element. Its biological properties are of interest due to its therapeutic potential, including in the treatment of diabetes mellitus. Vanadium deficiencies can lead to a range of pathologies. However, excessive concentration of this metal can cause irreversible damage to various tissues and organs. Vanadium toxicity mainly manifests in gastrointestinal symptoms, including diarrhea, vomiting, and weight reduction. Vanadium also exhibits hepatotoxic and nephrotoxic properties, including glomerulonephritis and pyelonephritis. Vanadium compounds may also lead to partial degeneration of the seminiferous epithelium of the seminiferous tubules in the testes and can affect male fertility. This paper describes the harmful effects of vanadium on the morphology and physiology of both animal and human tissues, including the digestive system, the urinary tract, and the reproductive system. What is more, the following study includes data concerning the correlation between the above-mentioned metal and its influence on fertility and fetus malformations. Additionally, this research identifies the doses of vanadium which lead to pathological alterations becoming visible within tissues. Moreover, this study includes information about the protective efficacy of some substances in view of the toxicity of vanadium.

钒对胃肠道、泌尿和生殖系统的毒性及其对生育和胎儿畸形的影响。
钒是一种过渡金属,对人类和动物都有独特而有益的影响。多年来,研究表明钒是人体必需的微量元素。由于其治疗潜力,包括治疗糖尿病,其生物学特性引起了人们的兴趣。缺钒会导致一系列的疾病。然而,这种金属的浓度过高会对各种组织和器官造成不可逆的损害。钒中毒主要表现为胃肠道症状,包括腹泻、呕吐和体重减轻。钒也表现出肝毒性和肾毒性,包括肾小球肾炎和肾盂肾炎。钒化合物也可能导致睾丸精小管的精管上皮部分变性,影响男性生育能力。本文介绍了钒对动物和人体组织的形态和生理的有害影响,包括消化系统、泌尿系统和生殖系统。更重要的是,下面的研究包含了上述金属及其对生育能力和胎儿畸形影响的相关数据。此外,本研究还确定了导致组织内可见的病理改变的钒剂量。此外,鉴于钒的毒性,本研究还包括一些物质的保护作用的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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