Classification and sensitivity analysis of the transmission dynamic of hepatitis B.

Q1 Mathematics

Theoretical Biology and Medical Modelling Pub Date : 2017-12-05 DOI:10.1186/s12976-017-0068-3

Tahir Khan, Il Hyo Jung, Amir Khan, Gul Zaman

{"title":"Classification and sensitivity analysis of the transmission dynamic of hepatitis B.","authors":"Tahir Khan, Il Hyo Jung, Amir Khan, Gul Zaman","doi":"10.1186/s12976-017-0068-3","DOIUrl":null,"url":null,"abstract":"Background: Hepatitis B infection caused by the hepatitis B virus is one of the most serious viral infections and a global health problem. In the transmission of hepatitis B infection, three different phases, i.e. acute infected, chronically infected, and carrier individuals, play important roles. Carrier individuals are especially significant, because they do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model.Methods: To demonstrate the transmission dynamic of hepatitis B, we investigate an epidemic model by dividing the infectious class into three subclasses, namely acute infected, chronically infected, and carrier individuals with both horizontal and vertical transmission.Results: Numerical results and sensitivity analysis of some important parameters are presented to show that the proportion of births without successful vaccination, perinatally infected individuals, and direct contact rate are highest risk factors for the spread of hepatitis B in the community.Conclusion: Our work provides a coherent platform for studying the full dynamics of hepatitis B and an effective direction for theoretical work.","PeriodicalId":51195,"journal":{"name":"Theoretical Biology and Medical Modelling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12976-017-0068-3","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical Biology and Medical Modelling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12976-017-0068-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Mathematics","Score":null,"Total":0}

引用次数: 3

Abstract

Background: Hepatitis B infection caused by the hepatitis B virus is one of the most serious viral infections and a global health problem. In the transmission of hepatitis B infection, three different phases, i.e. acute infected, chronically infected, and carrier individuals, play important roles. Carrier individuals are especially significant, because they do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model.

Methods: To demonstrate the transmission dynamic of hepatitis B, we investigate an epidemic model by dividing the infectious class into three subclasses, namely acute infected, chronically infected, and carrier individuals with both horizontal and vertical transmission.

Results: Numerical results and sensitivity analysis of some important parameters are presented to show that the proportion of births without successful vaccination, perinatally infected individuals, and direct contact rate are highest risk factors for the spread of hepatitis B in the community.

Conclusion: Our work provides a coherent platform for studying the full dynamics of hepatitis B and an effective direction for theoretical work.

Abstract Image

查看原文本刊更多论文

乙型肝炎传播动态的分类及敏感性分析。

背景:由乙型肝炎病毒引起的乙型肝炎感染是最严重的病毒性感染之一，也是一个全球性的卫生问题。在乙型肝炎感染的传播中，三个不同的阶段，即急性感染、慢性感染和携带者个体，起着重要的作用。携带者尤其重要，因为他们没有表现出任何症状，并且能够传播感染。在这里，我们评估了与乙型肝炎不同感染阶段相关的传播性，并建立了一个流行病模型。方法:为了证明乙型肝炎的传播动态，我们研究了一个流行病模型，将感染类别分为三个亚类，即急性感染，慢性感染和水平和垂直传播的携带者个体。结果:数值结果和一些重要参数的敏感性分析表明，未成功接种疫苗的出生比例、围产期感染人数和直接接触率是社区乙型肝炎传播的最高危险因素。结论:本研究为研究乙型肝炎的全动力学提供了一个连贯的平台，并为理论工作提供了有效的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Theoretical Biology and Medical Modelling MATHEMATICAL & COMPUTATIONAL BIOLOGY-

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Theoretical Biology and Medical Modelling is an open access peer-reviewed journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine. Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which Theoretical Biology and Medical Modelling operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.