The Contractile Phenotype of Dermal Fetal Fibroblasts in Scarless Wound Healing.

Q1 Medicine

Current Pathobiology Reports Pub Date : 2017-09-01 Epub Date: 2017-07-28 DOI:10.1007/s40139-017-0149-3

Aron Parekh, Patricia A Hebda

{"title":"The Contractile Phenotype of Dermal Fetal Fibroblasts in Scarless Wound Healing.","authors":"Aron Parekh, Patricia A Hebda","doi":"10.1007/s40139-017-0149-3","DOIUrl":null,"url":null,"abstract":"Purpose of review: Injured skin in the mammalian fetus can heal regeneratively due to the ability of fetal fibroblasts to effectively reorganize the extracellular matrix (ECM). This process occurs without fetal fibroblasts differentiating into highly contractile myofibroblasts which cause scarring and fibrosis in adult wounds. Here, we provide a brief review of fetal wound healing and the evidence supporting a unique contractile phenotype in fetal fibroblasts. Furthermore, we discuss the biomechanical role of the ECM in driving myofibroblast differentiation in wound healing and the implications for new clinical modalities based on the biophysical properties of fetal fibroblasts.Recent findings: We and others have found that fetal fibroblasts are refractory to the environmental stimuli necessary for myofibroblast differentiation in adult wound healing including mechanical stress.Summary: Understanding the biomechanical mechanisms that regulate the contractile phenotype of fetal fibroblasts may unlock new avenues for anti-scarring therapies that target myofibroblast differentiation of adult fibroblasts.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"5 3","pages":"271-277"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-017-0149-3","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Pathobiology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40139-017-0149-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/7/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 16

Abstract

Purpose of review: Injured skin in the mammalian fetus can heal regeneratively due to the ability of fetal fibroblasts to effectively reorganize the extracellular matrix (ECM). This process occurs without fetal fibroblasts differentiating into highly contractile myofibroblasts which cause scarring and fibrosis in adult wounds. Here, we provide a brief review of fetal wound healing and the evidence supporting a unique contractile phenotype in fetal fibroblasts. Furthermore, we discuss the biomechanical role of the ECM in driving myofibroblast differentiation in wound healing and the implications for new clinical modalities based on the biophysical properties of fetal fibroblasts.

Recent findings: We and others have found that fetal fibroblasts are refractory to the environmental stimuli necessary for myofibroblast differentiation in adult wound healing including mechanical stress.

Summary: Understanding the biomechanical mechanisms that regulate the contractile phenotype of fetal fibroblasts may unlock new avenues for anti-scarring therapies that target myofibroblast differentiation of adult fibroblasts.

Abstract Image

查看原文本刊更多论文

胎儿真皮成纤维细胞在无疤痕伤口愈合中的收缩表型。

综述目的:由于胎儿成纤维细胞能够有效地重组细胞外基质(ECM)，哺乳动物胎儿损伤的皮肤能够再生愈合。在这个过程中，胎儿成纤维细胞不会分化成高度收缩的肌成纤维细胞，后者会导致成人伤口的瘢痕和纤维化。在这里，我们提供胎儿伤口愈合的简要回顾和证据支持胎儿成纤维细胞独特的收缩表型。此外，我们讨论了ECM在伤口愈合中驱动肌成纤维细胞分化的生物力学作用，以及基于胎儿成纤维细胞生物物理特性的新临床模式的意义。最近的发现:我们和其他人发现胎儿成纤维细胞对成人伤口愈合中肌成纤维细胞分化所必需的环境刺激(包括机械应力)是不耐受的。摘要:了解调节胎儿成纤维细胞收缩表型的生物力学机制，可能为针对成人成纤维细胞的肌成纤维细胞分化的抗疤痕治疗开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.