The Role of Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery.

Q3 Medicine

Review of Diabetic Studies Pub Date : 2017-06-01 Epub Date: 2017-10-10 DOI:10.1900/RDS.2017.14.269

Karen L Søgaard, Christina Ellervik, Jannet Svensson, Steffen U Thorsen

{"title":"The Role of Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery.","authors":"Karen L Søgaard, Christina Ellervik, Jannet Svensson, Steffen U Thorsen","doi":"10.1900/RDS.2017.14.269","DOIUrl":null,"url":null,"abstract":"Background: The incidence of type 1 diabetes (T1D) is rising, which might be due to the influence of environmental factors. Biological and epidemiological evidence has shown that excess iron is associated with beta-cell damage and impaired insulin secretion.Aim: In this review, our aim was to assess the association between iron and the risk of T1D.Methods: A systematic literature search was performed in PubMed and EMBASE in July 2016. Studies investigating the effect of iron status/intake on the risk of developing T1D later were included, and study quality was evaluated. The results have been summarized in narrative form.Results: From a total of 931 studies screened, we included 4 observational studies evaluating iron intake from drinking water or food during early life and the risk of T1D. The quality of the studies was moderate to high assessed via the nine-star Newcastle Ottawa Scale. One out of the four studies included in this review found estimates of dietary iron intake to be associated with risk of T1D development, whereas three studies found no such relationship for estimates of iron in drinking water.Conclusions: The limited number of studies included found dietary iron, but not iron in drinking water, to be associated with risk of T1D. Further studies are needed to clarify the association between iron and risk of T1D, especially studies including measurements of body iron status.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115007/pdf/RevDiabeticStud-14-269.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Review of Diabetic Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1900/RDS.2017.14.269","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/10/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The incidence of type 1 diabetes (T1D) is rising, which might be due to the influence of environmental factors. Biological and epidemiological evidence has shown that excess iron is associated with beta-cell damage and impaired insulin secretion.

Aim: In this review, our aim was to assess the association between iron and the risk of T1D.

Methods: A systematic literature search was performed in PubMed and EMBASE in July 2016. Studies investigating the effect of iron status/intake on the risk of developing T1D later were included, and study quality was evaluated. The results have been summarized in narrative form.

Results: From a total of 931 studies screened, we included 4 observational studies evaluating iron intake from drinking water or food during early life and the risk of T1D. The quality of the studies was moderate to high assessed via the nine-star Newcastle Ottawa Scale. One out of the four studies included in this review found estimates of dietary iron intake to be associated with risk of T1D development, whereas three studies found no such relationship for estimates of iron in drinking water.

Conclusions: The limited number of studies included found dietary iron, but not iron in drinking water, to be associated with risk of T1D. Further studies are needed to clarify the association between iron and risk of T1D, especially studies including measurements of body iron status.

Abstract Image

查看原文本刊更多论文

铁在 1 型糖尿病病因学中的作用：对一个长期谜团的新证据的系统回顾。

背景：1型糖尿病（T1D）的发病率正在上升，这可能是由于环境因素的影响。生物学和流行病学证据表明，过量的铁与β细胞损伤和胰岛素分泌受损有关：方法：我们于 2016 年 7 月在 PubMed 和 EMBASE 中进行了系统性文献检索。方法：2016 年 7 月在 PubM 和 EMBASE 中进行了系统性文献检索，纳入了调查铁状况/摄入量对日后罹患 T1D 风险影响的研究，并对研究质量进行了评估。研究结果以叙述形式进行了总结：结果：在总共筛选出的 931 项研究中，我们纳入了 4 项观察性研究，这些研究评估了生命早期从饮用水或食物中摄入的铁与 T1D 风险之间的关系。根据纽卡斯尔-渥太华九星级量表（Newcastle Ottawa Scale）评估，这些研究的质量为中等至高等。本综述所纳入的四项研究中，有一项研究发现膳食铁摄入量与T1D发病风险有关，而有三项研究发现饮用水中铁的摄入量与T1D发病风险没有关系：结论：纳入的有限研究发现，膳食中的铁与 T1D 的发病风险有关，但饮用水中的铁与 T1D 的发病风险无关。要厘清铁与 T1D 风险之间的关系，还需要进一步的研究，尤其是包括测量体内铁状况的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Review of Diabetic Studies Medicine-Internal Medicine

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.