Pathophysiology of Keratoconus: What Do We Know Today.

IF 0.4 Q4 OPHTHALMOLOGY

Open Ophthalmology Journal Pub Date : 2017-07-31 eCollection Date: 2017-01-01 DOI:10.2174/1874364101711010252

Uri Soiberman, James W Foster, Albert S Jun, Shukti Chakravarti

引用次数: 30

Abstract

Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

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圆锥角膜的病理生理学:我们今天所知道的。

圆锥角膜是一种常见的角膜扩张，可导致进行性视力损害。大量的研究表明，圆锥角膜中存在异常的蛋白表达模式。然而，导致这种疾病的具体机制仍然不清楚。本综述旨在提供最新的形态学研究，将这些早期研究与目前蛋白质组学、生化和细胞培养研究的发现联系起来，并推测可能的致病途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Ophthalmology Journal OPHTHALMOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： The Open Ophthalmology Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in ophthalmology, including use of ophthalmological therapies, devices and surgical techniques. The Open Ophthalmology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.