Photobiomodulation Therapy Alleviates Tissue Fibroses Associated with Chronic Graft-Versus-Host Disease: Two Case Reports and Putative Anti-Fibrotic Roles of TGF-β.

Q2 Medicine
Photomedicine and laser surgery Pub Date : 2018-02-01 Epub Date: 2017-10-19 DOI:10.1089/pho.2017.4297
Joel B Epstein, Judith E Raber-Durlacher, Marie-Charlotte Huysmans, Maria C E Schoordijk, Jerry E Cheng, Rene-Jean Bensadoun, Praveen R Arany
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引用次数: 18

Abstract

Objective: Patients who receive allogeneic hematopoietic stem cell transplantation may experience oral complications due to chronic graft-versus-host disease (cGVHD). The manifestations may include progressive sclerosis-like changes that may involve various body sites, including the oropharynx.

Methods and results: We present two cGVHD cases of oropharyngeal fibrotic changes that affected functions that were treated with photobiomodulation (PBM) therapy. These case reports suggest that PBM therapy represents an additional, innovative approach affecting discrete phases in cGVHD-associated fibrotic changes.

Conclusions: We discuss these observations in the context of currently understood molecular mechanisms, especially induction of transforming growth factor beta and NFκB that appear to be counter-intuitive to their known roles in matrix synthesis and inflammation that contribute to tissue fibroses. The clinical benefit noted in the two cases presented clearly indicates that there are distinct mechanistic and biological insights in the regulation of these molecular pathways in determining therapeutic efficacy with PBM therapy.

光生物调节治疗减轻慢性移植物抗宿主病相关的组织纤维化:两例报告和TGF-β的抗纤维化作用
目的:接受同种异体造血干细胞移植的患者可能会因慢性移植物抗宿主病(cGVHD)而出现口腔并发症。表现可包括进行性硬化样改变,可累及身体各部位,包括口咽部。方法和结果:我们报告了两例cGVHD患者的口咽纤维化改变,影响功能,并采用光生物调节(PBM)治疗。这些病例报告表明,PBM治疗是影响cgvhd相关纤维化变化离散期的一种额外的创新方法。结论:我们在目前了解的分子机制的背景下讨论了这些观察结果,特别是诱导转化生长因子β和NFκB,这似乎与它们在基质合成和炎症中导致组织纤维化的已知作用相反。这两个病例的临床获益清楚地表明,在决定PBM治疗效果的这些分子途径的调节中,有不同的机制和生物学见解。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery (formerly Photomedicine and Laser Surgery) is the essential journal for cutting-edge advances and research in phototherapy, low-level laser therapy (LLLT), and laser medicine and surgery. The Journal delivers basic and clinical findings and procedures to improve the knowledge and application of these techniques in medicine.
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