Impact of CYP2D6 and ADRB1 polymorphisms on heart rate of post-PCI patients treated with metoprolol.

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2024-05-31 DOI:10.2217/pgs-2017-0203

Xiaofeng Gao, Huan Wang, Hui Chen

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引用次数: 0

Abstract

Aim: To explore the effect of CYP2D6*10 (100C > T) and ADRB1 1165 G > C polymorphisms on heart rate of post-PCI (percutaneous coronary intervention) patients treated with metoprolol succinate sustained-release tablets. Methods: A total of 756 inpatients with metoprolol succinate sustained-release tablets were selected and the genotypes of CYP2D6*10 and ADRB1 1165G > C were detected in 319 patients using gene chip detection. The target heart rate was defined as a resting heart rate < 70 beats/min. Clinical data were collected. Results: A total of 319 inpatients were enrolled in the study. The mutant allele frequencies of CYP2D6 and ADRB1 were 57.21 and 69.44%, respectively. Whatever the dose of metoprolol, the heart rates were lower in patients with homozygous mutation of CYP2D6 than those with heterozygous mutation and wild-type (p < 0.05). Nevertheless, this effect was not seen between different genotypes of ADRB1. Logistic regression analysis showed that the dose of metoprolol and the genotypes of CYP2D6 were predictors of heart rate <70 beats/min in these patients. Further multivariate analysis indicated that patients with homozygous mutation had better control of heart rates compared with those with wild-type and heterozygous mutation of CYP2D6*10 genotypes (all: p < 0.001). Conclusion:CYP2D6*10 polymorphisms were associated with the heart rate of post-PCI patients treated with metoprolol succinate sustained-release tablets.

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CYP2D6和ADRB1多态性对接受美托洛尔治疗的PCI术后患者心率的影响

目的：探讨CYP2D6*10（100C > T）和ADRB1 1165 G > C多态性对接受琥珀酸美托洛尔缓释片治疗的PCI（经皮冠状动脉介入治疗）后患者心率的影响：方法：选取了756例使用琥珀酸美托洛尔缓释片的住院患者，使用基因芯片检测法检测了319例患者的CYP2D6*10和ADRB1 1165G > C基因型。目标心率定义为静息心率结果共有 319 名住院患者参与了研究。CYP2D6和ADRB1的突变等位基因频率分别为57.21%和69.44%。无论美托洛尔的剂量是多少，CYP2D6 基因同源突变患者的心率都低于杂合突变和野生型患者（p 结论：CYP2D6*10 基因突变患者的心率低于杂合突变和野生型患者（p 结论：CYP2D6*10 基因突变患者的心率低于杂合突变和野生型患者）：CYP2D6*10多态性与接受琥珀酸美托洛尔缓释片治疗的PCI术后患者的心率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.