Autophagy and Ferroptosis - What's the Connection?

Q1 Medicine

Current Pathobiology Reports Pub Date : 2017-06-01 Epub Date: 2017-04-20 DOI:10.1007/s40139-017-0139-5

Rui Kang, Daolin Tang

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Abstract

Purpose of review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level.

Recent findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy.

Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis, but also raises new insights regarding regulated cell death.

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自噬和铁蛋白沉积--有什么联系？

综述的目的：自噬是一种保守的细胞内降解系统，在细胞死亡中扮演着双重角色，具体取决于环境和阶段。铁过氧化是一种新的细胞死亡调控形式，主要依赖于铁积累和脂质过氧化。在这篇综述中，我们总结了自噬和铁突变的过程，并讨论了它们在分子水平上的相互影响机制：最初的研究表明，铁突变在形态学、生物化学和遗传学上与自噬和其他类型的细胞死亡不同。然而，最近的研究表明，铁变态反应的激活确实依赖于自噬的诱导。此外，许多铁变态调节因子，如 SLC7A11、GPX4、NRF2、p53、HSPB1、CISD1、FANCD2 和 ACSL4 已被确定为自噬的潜在调节因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.