Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration.

Divya Pankajakshan, Devendra K Agrawal
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引用次数: 66

Abstract

Mesenchymal stem cell therapy show great optimism in the treatment of several diseases. MSCs are attractive candidates for cell therapy because of easy isolation, high expansion potential giving unlimited pool of transplantable cells, low immunogenicity, amenability to ex vivo genetic modification, and multipotency. The stem cells orchestrate the repair process by various mechanisms such as transdifferentiation, cell fusion, microvesicles or exosomes and most importantly by secreting paracrine factors. The MSCs release several angiogenic, mitogenic, anti-apoptotic, anti-inflammatory and anti-oxidative factors that play fundamental role in regulating tissue repair in various vascular and cardiac diseases. The therapeutic release of these factors by the cells can be enhanced by several strategies like genetic modification, physiological and pharmacological preconditioning, improved cell culture and selection methods, and biomaterial based approaches. The current review describes the impact of paracrine factors released by MSCs on vascular repair and regeneration in myocardial infarction, restenosis and peripheral artery disease, and the various strategies adopted to enhance the release of these paracrine factors to enhance organ function.

Abstract Image

Abstract Image

血管修复与再生中的间充质干细胞旁分泌因子。
间充质干细胞治疗在几种疾病的治疗中显示出很大的前景。间充质干细胞因其易于分离、具有无限的可移植细胞池、低免疫原性、易于体外基因修饰和多能性而成为细胞治疗的有吸引力的候选者。干细胞通过各种机制,如转分化、细胞融合、微泡或外泌体,以及最重要的分泌旁分泌因子来协调修复过程。MSCs释放多种血管生成、有丝分裂、抗凋亡、抗炎和抗氧化因子,在调节各种血管和心脏疾病的组织修复中发挥重要作用。细胞对这些因子的治疗性释放可以通过几种策略来增强,如基因修饰、生理和药理学预处理、改进的细胞培养和选择方法以及基于生物材料的方法。本文综述了MSCs释放的旁分泌因子在心肌梗死、再狭窄和外周动脉疾病中对血管修复和再生的影响,以及促进这些旁分泌因子释放以增强器官功能的各种策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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