Noncoding RNAs in Polycomb and Trithorax Regulation: A Quantitative Perspective.

IF 8.7 1区 生物学 Q1 GENETICS & HEREDITY
Annual review of genetics Pub Date : 2017-11-27 Epub Date: 2017-09-15 DOI:10.1146/annurev-genet-120116-023402
Leonie Ringrose
{"title":"Noncoding RNAs in Polycomb and Trithorax Regulation: A Quantitative Perspective.","authors":"Leonie Ringrose","doi":"10.1146/annurev-genet-120116-023402","DOIUrl":null,"url":null,"abstract":"<p><p>The question of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulation has been on an extraordinary journey over the last three decades. Favored models have risen and fallen, and healthy debates have swept back and forth. The field has recently reached a critical mass of compelling data that throws light on several previously unresolved issues. The time is ripe for a fruitful combination of these findings with two other long-running avenues of research, namely the biochemical properties of the PcG/TrxG system and the application of theoretical mathematical models toward an understanding of the system's regulatory properties. I propose that integrating our current knowledge of noncoding RNA into a quantitative biochemical and theoretical framework for PcG and TrxG regulation has the potential to reconcile several apparently conflicting models and identifies fascinating questions for future research.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"51 ","pages":"385-411"},"PeriodicalIF":8.7000,"publicationDate":"2017-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-genet-120116-023402","citationCount":"29","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-genet-120116-023402","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/9/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 29

Abstract

The question of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulation has been on an extraordinary journey over the last three decades. Favored models have risen and fallen, and healthy debates have swept back and forth. The field has recently reached a critical mass of compelling data that throws light on several previously unresolved issues. The time is ripe for a fruitful combination of these findings with two other long-running avenues of research, namely the biochemical properties of the PcG/TrxG system and the application of theoretical mathematical models toward an understanding of the system's regulatory properties. I propose that integrating our current knowledge of noncoding RNA into a quantitative biochemical and theoretical framework for PcG and TrxG regulation has the potential to reconcile several apparently conflicting models and identifies fascinating questions for future research.

非编码rna在多梳和三胸调节中的定量研究。
在过去的三十年里,关于非编码rna如何参与Polycomb group (PcG)和Trithorax group (TrxG)调控的问题已经走过了一段不寻常的旅程。受青睐的模式有起有落,健康的辩论也在此起彼伏。该领域最近获得了大量令人信服的数据,这些数据揭示了一些以前未解决的问题。将这些发现与另外两项长期研究相结合的时机已经成熟,即PcG/TrxG系统的生化特性和应用理论数学模型来理解系统的调控特性。我建议将我们目前对非编码RNA的知识整合到PcG和TrxG调控的定量生化和理论框架中,有可能调和几个明显冲突的模型,并为未来的研究确定有趣的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annual review of genetics
Annual review of genetics 生物-遗传学
CiteScore
18.30
自引率
0.90%
发文量
17
期刊介绍: The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信