[Efficacy of oral hyposensitization treatment in house dust mite allergy (author's transl)].

Abstract

32 children with perennial asthma and/or rhinitis due to house dust mite (HDM) allergy have been hyposensitized orally for a period of 42 weeks. The sensitization against HDM was confirmed by skin testing, RAST determinations and nasal provocation tests before and after treatment. The trial was double-blind, with 17 patients receiving the HDM extract and 15 receiving placebo. Patients returned for assessment at 6, 18, 30, and 42 weeks, nasal airways resistance testing, lung function tests (FVC), FEV1, PEF) and clinical evaluations were performed. The results of the subjective and objective assessments failed to demonstrate any superiority of oral hyposensitization with house dust mite extract compared to placebo.