Pancreatogastrostomy versus Pancreatojejunostomy: An Up-to-Date Meta-Analysis of RCTs.

IF 1.6 Q4 ONCOLOGY

International Journal of Surgical Oncology Pub Date : 2017-01-01 Epub Date: 2017-07-17 DOI:10.1155/2017/7526494

Konstantinos Perivoliotis, Eleni Sioka, Athina Tatsioni, Ioannis Stefanidis, Elias Zintzaras, Dimitrios Zacharoulis

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引用次数: 16

Abstract

Background: A meta-analysis was conducted in order to provide an up-to-date comparison of pancreatogastrostomy (PG) and pancreatojejunostomy (PJ), after pancreatoduodenectomy (PD), in terms of clinically significant postoperative pancreatic fistula (POPF) and other postoperative complications.

Methods: This meta-analysis was conducted according to the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. A systematic literature search in MEDLINE and Cochrane Central Register of Controlled Clinical Trials was performed. Fixed Effects or Random Effects model was used, based on the Cochran Q test.

Results: In total, 10 studies (1629 patients) were included. There was no statistical significance between PG and PJ regarding the rate of clinically significant POPF (OR: 0.70, 95%CI: 0.46-1.06). PG was associated with a higher rate of postpancreatoduodenectomy haemorrhage (PPH) (OR: 1.52, 95%CI: 1.08-2.14). There was no difference between the two techniques in terms of clinically significant PPH (OR: 1.35, 95%CI: 0.95-1.93) and clinically significant postoperative delayed gastric emptying (DGE) (OR: 0.98, 95%CI: 0.59-1.63).

Discussion: There is no difference between the two anastomotic techniques regarding the rate of clinically significant POPF. Given several limitations, more large scale high quality RCTs are required.

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查看原文本刊更多论文

胰胃吻合术与胰空肠吻合术:一项最新的随机对照试验荟萃分析。

背景:一项荟萃分析旨在比较胰十二指肠切除术(PD)后胰胃吻合术(PG)和胰空肠吻合术(PJ)在临床上显著的术后胰瘘(POPF)和其他术后并发症方面的最新情况。方法:本荟萃分析依据PRISMA指南和Cochrane干预措施系统评价手册进行。在MEDLINE和Cochrane对照临床试验中央注册库中进行了系统的文献检索。采用固定效应或随机效应模型，基于Cochran Q检验。结果:共纳入10项研究(1629例患者)。PG组与PJ组临床显著性POPF发生率比较，差异无统计学意义(OR: 0.70, 95%CI: 0.46 ~ 1.06)。PG与胰十二指肠切除术后出血(PPH)发生率较高相关(OR: 1.52, 95%CI: 1.08-2.14)。两种方法在临床显著的PPH (OR: 1.35, 95%CI: 0.95-1.93)和临床显著的术后胃排空延迟(DGE) (OR: 0.98, 95%CI: 0.59-1.63)方面无差异。讨论:两种吻合技术在临床上显著的POPF发生率方面没有差异。考虑到一些限制，需要更多的大规模高质量随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Surgical Oncology ONCOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.