Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx.

Q2 Medicine

BMC Clinical Pathology Pub Date : 2017-11-25 eCollection Date: 2017-01-01 DOI:10.1186/s12907-017-0061-0

Nawal Hammas, Najib Benmansour, Mohamed Nour-Dine El Alami El Amine, Laila Chbani, Hind El Fatemi

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Abstract

Background: Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Therefore, it must be known by clinicians, pathologists and oncologists. In this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome.

Case presentation: An 81-year-old Morrocan man, smoker for 40 years, presented with a 1 year history of dysphonia, dyspnea and dysphagia. Laryngoscopy showed a mass occupying supraglottic, glottic and subglottic levels of the larynx. Cervico-thoracic computed tomography scan showed a laryngeal wall thickening with cervical lymphadenopathy. Laryngeal biopsy was performed. Microscopic analysis and immunohistochemistry confirmed the diagnosis of laryngeal lymphoepithelial carcinoma. Immunostaining for LMP1 was negative.

Conclusion: Laryngeal lymphoepithelial carcinoma is an extremely rare and an aggressive tumor. It is rarely associated with the EBV. It must be regarded as a distinct entity. Radiotherapy is advisable as the unique therapy for local tumor. A correct diagnosis and a close collaboration between the pathologist and clinicians is mandatory for an optimal treatment strategy.

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淋巴上皮癌：喉部罕见肿瘤的病例报告。

背景：淋巴上皮癌是一种主要在鼻咽部确诊的肿瘤，但在非鼻咽部的多个部位也有发生。喉部淋巴上皮癌极为罕见，应与鳞状细胞癌区分开来。因此，临床医生、病理学家和肿瘤学家必须了解这种疾病。在本病例报告中，我们将讨论其病因、流行病学、临床、病理和治疗方面及其结果：一名 81 岁的摩洛哥男子，吸烟 40 年，出现发音障碍、呼吸困难和吞咽困难病史 1 年。喉镜检查显示，喉部声门上、声门和声门下有肿块。颈胸计算机断层扫描显示喉壁增厚并伴有颈淋巴结病。进行了喉活检。显微镜分析和免疫组化证实了喉淋巴上皮癌的诊断。LMP1免疫染色呈阴性：结论：喉淋巴上皮癌是一种极其罕见的侵袭性肿瘤。结论：喉淋巴上皮癌是一种极其罕见的侵袭性肿瘤，很少与 EB 病毒相关。必须将其视为一个独特的实体。放疗是治疗局部肿瘤的唯一方法。正确的诊断以及病理学家和临床医生之间的密切合作是最佳治疗策略的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.