Production of antibiotic SU-2 complex by a 2-deoxystreptamine idiotroph of Micromonospora sagamiensis.

H Kase, S Kitamura, K Nakayama
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引用次数: 10

Abstract

A 2-deoxystreptamine idiotrophic mutant of Micromonospora sagamiensis, KY 11509, was found to produce unknown antibacterial substances, which were named SU-2 complex. Each component, SU-1, SU-2 and SU-3 were isolated from a culture broth of KY 11509. Chromatographic data suggested that these components were new antibiotics. The antibiotics exhibited potent and broad spectrum of antibacterial activity. The amount of SU-1, SU-2 and SU-3 production reached their maximum level (197, 82 and 58 micrograms/liter, respectively) in 3 to 4 days. Addition of cobalt chloride markedly stimulated SU-1 production but suppressed SU-2 and SU-3 production. Isolation of a mutant possessing a higher productivity of SU-2 complex is also described.

sagamimicromonospora的2-脱氧链胺异养体生产抗生素SU-2复合物。
摘要在sagamiensis小单孢子菌(Micromonospora sagamiensis)中发现了一个2-脱氧链胺异营养突变体KY 11509,该突变体产生未知的抗菌物质,命名为SU-2复合物。SU-1、SU-2和SU-3分别从ky11509培养液中分离得到。色谱数据表明这些成分为新型抗生素。抗生素表现出强大的广谱抗菌活性。SU-1、SU-2和SU-3的产量在3 ~ 4天后达到最大值(分别为197、82和58微克/升)。氯化钴的加入显著提高了SU-1的产量,但抑制了SU-2和SU-3的产量。还描述了具有较高生产力的SU-2复合体的突变体的分离。
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