{"title":"Production of antibiotic SU-2 complex by a 2-deoxystreptamine idiotroph of Micromonospora sagamiensis.","authors":"H Kase, S Kitamura, K Nakayama","doi":"10.7164/antibiotics.35.385","DOIUrl":null,"url":null,"abstract":"<p><p>A 2-deoxystreptamine idiotrophic mutant of Micromonospora sagamiensis, KY 11509, was found to produce unknown antibacterial substances, which were named SU-2 complex. Each component, SU-1, SU-2 and SU-3 were isolated from a culture broth of KY 11509. Chromatographic data suggested that these components were new antibiotics. The antibiotics exhibited potent and broad spectrum of antibacterial activity. The amount of SU-1, SU-2 and SU-3 production reached their maximum level (197, 82 and 58 micrograms/liter, respectively) in 3 to 4 days. Addition of cobalt chloride markedly stimulated SU-1 production but suppressed SU-2 and SU-3 production. Isolation of a mutant possessing a higher productivity of SU-2 complex is also described.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"385-90"},"PeriodicalIF":0.0000,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.385","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Antibiotics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7164/antibiotics.35.385","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
A 2-deoxystreptamine idiotrophic mutant of Micromonospora sagamiensis, KY 11509, was found to produce unknown antibacterial substances, which were named SU-2 complex. Each component, SU-1, SU-2 and SU-3 were isolated from a culture broth of KY 11509. Chromatographic data suggested that these components were new antibiotics. The antibiotics exhibited potent and broad spectrum of antibacterial activity. The amount of SU-1, SU-2 and SU-3 production reached their maximum level (197, 82 and 58 micrograms/liter, respectively) in 3 to 4 days. Addition of cobalt chloride markedly stimulated SU-1 production but suppressed SU-2 and SU-3 production. Isolation of a mutant possessing a higher productivity of SU-2 complex is also described.