Circadian dysregulation in Parkinson's disease

Q2 Medicine

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2017-01-01 DOI:10.1016/j.nbscr.2016.11.001

Aleksandar Videnovic , Diego Golombek

引用次数: 41

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD.

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帕金森病的昼夜节律失调。

帕金森病（PD）是第二常见的神经退行性疾病，仅在美国就有超过100万人受到影响。帕金森病的特点是运动和非运动表现过多，这是由多巴胺能神经元的进行性变性和其他几种神经递质的失衡引起的。越来越多的证据表明帕金森病的昼夜节律系统发生了显著变化。考虑到多巴胺在昼夜节律调节中的关键作用以及昼夜节律影响在多巴胺代谢中的作用，这并不奇怪。在这篇综述中，我们介绍了检测帕金森病昼夜节律系统功能的基础和临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Sleep and Circadian Rhythms Neuroscience-Behavioral Neuroscience

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Neurobiology of Sleep and Circadian Rhythms is a multidisciplinary journal for the publication of original research and review articles on basic and translational research into sleep and circadian rhythms. The journal focuses on topics covering the mechanisms of sleep/wake and circadian regulation from molecular to systems level, and on the functional consequences of sleep and circadian disruption. A key aim of the journal is the translation of basic research findings to understand and treat sleep and circadian disorders. Topics include, but are not limited to: Basic and translational research, Molecular mechanisms, Genetics and epigenetics, Inflammation and immunology, Memory and learning, Neurological and neurodegenerative diseases, Neuropsychopharmacology and neuroendocrinology, Behavioral sleep and circadian disorders, Shiftwork, Social jetlag.