Interplay between antiretroviral therapy and oxidative stress in HIV seropositive patients.

Abstract

Background: HIV infection results in a decline of CD4+ T-cells count and ultimately results in qualitative impairments of CD4+ T-cell function. Antiretroviral therapy results in an increase in the number of CD4+ cells and the functional reconstitution of the immune system. However, patients on therapy commonly experience adverse effects; management of HIV infection thus becomes a balancing act between the benefits of HIV suppression and the risks of drug toxicity with Highly Active Antiretroviral Therapy (HAART). Purpose and Findings: This review intended to look into the relationship between adverse effects with HAART in relation to its induction of oxidative stress in the host. From literature,. HAART has been shown to induce oxidative stress by several biochemical mechanisms. However, the induction of oxidative stress by HAART is minimal compared to HIV induction of oxidative stress-in the host. The use of HAART in the management of HIV-AIDS thus remains inevitable and the combination with exogenous antioxidants is advocated. Exogenous antioxidants mop up infection induced reactive oxygen species (ROS), and may also be beneficial in ameliorating some of the adverse effects induced by HAART.

Conclusion: Further review on individual adverse effects of ART is recommended and our ongoing research on the teratogenic potentials of HAART will also be very relevant on this subject.