Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012116689001

In Joon Lee, Ji Yong Park, Young-Il Kim, Yun-Sang Lee, Jae Min Jeong, Jaeil Kim, Euishin Edmund Kim, Keon Wook Kang, Dong Soo Lee, Seonji Jeong, Eun Jeong Kim, Young Il Kim, Jin Wook Chung

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引用次数: 9

Abstract

The aim of this study is to evaluate the localization of ^99mTc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered ^99mTc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of ^99mTc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs. Intra-arterial delivery of SPIO with Lipiodol might be a good drug delivery system targeting the hepatic tumors, as confirmed by image-based analysis.

Abstract Image

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利用SPECT/CT和MRI对动脉内注入锝-99m标记SPIO后肿瘤定位的影像学分析。

本研究的目的是通过基于图像的分析来评估99mtc标记的葡聚糖包被超顺磁性氧化铁(SPIO)纳米颗粒对肝脏肿瘤的定位。我们将99mTc-SPIO在加/不加lipodol的情况下静脉或动脉内注射，通过伽马闪烁成像、单光子发射计算机断层扫描(SPECT)和磁共振成像(MRI)对兔肝肿瘤的定位进行比较。基于伽玛和SPECT图像的分析显示，在Lipiodol IA注入99mTc-SPIO后，肿瘤对正常肝实质的摄取比最高，这与肝脏mri信号降低的趋势有很好的相关性。基于图像的分析证实，在动脉内给药SPIO与lipodol可能是一种很好的靶向肝脏肿瘤的给药系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.