A nationwide outbreak of listeriosis associated with cold-cuts, Sweden 2013-2014.

Q1 Environmental Science
Infection Ecology and Epidemiology Pub Date : 2017-06-13 eCollection Date: 2017-01-01 DOI:10.1080/20008686.2017.1324232
Viktor Dahl, Lena Sundqvist, Ingela Hedenström, Margareta Löfdahl, Erik Alm, Håkan Ringberg, Mats Lindblad, Anders Wallensten, Susanne Thisted Lambertz, Cecilia Jernberg
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引用次数: 13

Abstract

In January 2014, the Public Health Agency of Sweden noticed an increase in listeriosis cases. Isolates from 10 cases had identical pulsed field gel electrophoresis (PFGE) profiles, suggesting a common source. We investigated the outbreak to identify the source and stop transmission. We looked for cases in 2013-2014 and also compared cases notified after February 2014 to randomly selected controls. We surveyed food items consumed two weeks prior to symptom onset. Listeria monocytogenes isolates found by food producers were PFGE-typed. Patient and food isolates with the outbreak PFGE profile were whole-genome sequenced and 51 cases with identical PFGE profile were identified; 12/20 cases and 108/186 controls responded to the survey. All cases were exposed to cold-cuts, compared with 72% of controls (p = 0.034). Five isolates of L. monocytogenes with the outbreak PFGE profile were found in cold-cuts from a food producer which stopped production in February 2014, but cases appeared until October 2014. Whole-genome sequencing showed that cold-cut and patient isolates differed by eight single nucleotide polymorphisms. Three patient isolates differed more and were probably not part of the outbreak. Epidemiological and microbiological results indicated cold-cuts as a possible source of the outbreak.

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2013-2014年瑞典与冷盘相关的李斯特菌病全国暴发。
2014年1月,瑞典公共卫生署注意到李斯特菌病病例有所增加。10例分离株具有相同的脉冲场凝胶电泳(PFGE)图谱,提示来源相同。我们调查了疫情,以确定源头并阻止传播。我们寻找2013-2014年的病例,并将2014年2月以后报告的病例与随机选择的对照进行比较。我们调查了症状出现前两周食用的食物。食品生产商发现的单核增生李斯特菌分离株为pfge型。对具有暴发PFGE特征的患者和食物分离株进行全基因组测序,鉴定出51例具有相同PFGE特征的病例;12/20的病例和108/186的对照组回应了调查。与72%的对照组相比,所有病例均接受冷切(p = 0.034)。在2014年2月停止生产的一家食品生产商的冷切肉中发现了5株具有暴发PFGE特征的单核增生乳杆菌,但直到2014年10月才出现病例。全基因组测序显示冷切和患者分离株存在8个单核苷酸多态性差异。三种分离的患者差异更大,可能不属于疫情的一部分。流行病学和微生物学结果表明,冷切可能是疫情的来源。
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来源期刊
Infection Ecology and Epidemiology
Infection Ecology and Epidemiology Environmental Science-Environmental Science (miscellaneous)
CiteScore
8.70
自引率
0.00%
发文量
4
审稿时长
12 weeks
期刊介绍: Infection Ecology & Epidemiology aims to stimulate inter-disciplinary collaborations dealing with a range of subjects, from the plethora of zoonotic infections in humans, over diseases with implication in wildlife ecology, to advanced virology and bacteriology. The journal specifically welcomes papers from studies where researchers from multiple medical and ecological disciplines are collaborating so as to increase our knowledge of the emergence, spread and effect of new and re-emerged infectious diseases in humans, domestic animals and wildlife. Main areas of interest include, but are not limited to: 1.Zoonotic microbioorganisms 2.Vector borne infections 3.Gastrointestinal pathogens 4.Antimicrobial resistance 5.Zoonotic microbioorganisms in changing environment
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