Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012117709384

Katja Steiger, Anna-Melissa Schlitter, Wilko Weichert, Irene Esposito, Hans-Jürgen Wester, Johannes Notni

引用次数: 23

Abstract

ß₆-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of α_vß₆-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel α_vß₆-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

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αvβ6-胰蛋白酶成像在胰腺癌及其前驱病变临床管理中的应用前景。

对大量胰腺导管腺癌（PDAC，383个原发肿瘤、7个淋巴结和8个远处转移瘤）和34个胰腺上皮内瘤（PanIN）标本进行的ß6整合素免疫组化分析显示，αvß6整合素在PDAC原发肿瘤（88%）和几乎所有转移瘤以及PanIN（57%）中的表达率很高。这些发现凸显了新型αvß6整合素靶向正电子发射断层扫描（PET）放射性药物Ga-68-Avebehexin在胰腺癌早期诊断中的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.