{"title":"Two-Pore Channels and Parkinson's Disease: Where's the Link?","authors":"Pilar Rivero-Ríos, Belén Fernández, Jesús Madero-Pérez, María Romo Lozano, Sabine Hilfiker","doi":"10.1166/msr.2016.1051","DOIUrl":null,"url":null,"abstract":"<p><p>Two-pore channels are endolysosomal Ca<sup>2+</sup> release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca<sup>2+</sup>-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.</p>","PeriodicalId":74176,"journal":{"name":"Messenger (Los Angeles, Calif. : Print)","volume":"5 1-2","pages":"67-75"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436604/pdf/emss-72808.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Messenger (Los Angeles, Calif. : Print)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1166/msr.2016.1051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Two-pore channels are endolysosomal Ca2+ release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca2+-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.
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