Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2017-01-01 Epub Date: 2017-04-13 DOI:10.1155/2017/4689465
Allan Golding, Dana Shively, David N Bimston, R Mack Harrell
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引用次数: 16

Abstract

Objective. Retrospective studies have found that noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) exhibits highly indolent clinical behavior. We studied the clinical features of our patients with noninvasive EFVPTC tumors culled from a community endocrine surgical practice registry over the past four years. Methods. We interrogated the Memorial Center for Integrative Endocrine Surgery (MCIES) Registry for all recorded encapsulated follicular variant of papillary cancer pathologic diagnoses. We identified a subgroup of patients without capsular or vascular invasion and studied their clinical characteristics. Results. Thirty-seven patients met inclusion and exclusion criteria. The typical patient was young and female. Nodules averaged 3.1 cm in greatest dimension by ultrasound evaluation. Thirteen patients were found to have synchronous malignancies elsewhere in the thyroid (35%). At the time of this writing, we have not seen a clinical recurrence in any of our 37 noninvasive EFVPTC patients. Conclusions. Early clinical follow-up data suggests that the majority of noninvasive EFVPTC tumors exhibit indolent behavior, but clinical decision-making with regard to completion thyroidectomy, central lymph node dissection, and adjunctive radioiodine therapy often depends on the amount and type of synchronous thyroid cancer detected elsewhere in the thyroid gland and the central neck.

Abstract Image

无创包膜滤泡型甲状腺乳头状癌:来自社区内分泌外科实践的临床经验。
目标。回顾性研究发现,非侵袭性囊泡型甲状腺乳头状癌(EFVPTC)表现出高度惰性的临床行为。我们研究了过去四年来从社区内分泌外科实践登记处挑选的非侵入性EFVPTC肿瘤患者的临床特征。方法。我们询问了综合内分泌外科纪念中心(MCIES)登记处记录的所有包膜滤泡变异型乳头状癌病理诊断。我们确定了一组没有被囊或血管侵犯的患者,并研究了他们的临床特征。结果。37例患者符合纳入和排除标准。典型的患者为年轻女性。超声检查结节平均最大尺寸为3.1 cm。13例患者在甲状腺其他部位发现同步恶性肿瘤(35%)。在撰写本文时,我们尚未发现37例无创EFVPTC患者的临床复发。结论。早期临床随访资料显示,大多数非侵袭性EFVPTC肿瘤表现为惰性行为,但临床决定是否完成甲状腺切除术、中央淋巴结清扫和辅助放射性碘治疗,往往取决于甲状腺和中央颈部其他部位检测到的同步甲状腺癌的数量和类型。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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