Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash
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引用次数: 11

Abstract

Gastrointestinal complications are common after coronary artery bypass graft surgery. These complications are ranged from nausea and vomiting to mesenteric ischemia and liver failure. It seems that nausea, vomiting, and constipation are related to magnesium deficiency. This study was designed to examine the effect of oral magnesium supplementation on the incidence of gastrointestinal complications in patients undergoing cardiac surgery. In a single blinded randomized clinical trial, 102 patients who were undergoing coronary artery bypass graft surgery were randomly allocated into two groups, 52 patients in the intervention and 50 patients in control group. Patients in the experimental group received 800 milligram magnesium oxide (2 tablets each of them containing 240 mg elemental magnesium) daily from the admission to discharge from hospital. The incidence of post-operative nausea and vomiting, constipation, and atrial fibrillation was compared between the groups. Our results showed that postoperative hypomagnesemia is present in 41.20 and 70.80 percent of the patients in the intervention and control group patients, respectively. The overall incidence of constipation was 62%. Patients who received magnesium supplementation experienced less atrial fibrillation, nausea, vomiting, and constipation. Our data showed that oral magnesium supplementation could reduce the postoperative complications. Despite the better status in the intervention group, the hypomagnesemia was present in many of intervention group patients. It seems that supplementation with higher doses is needed.

口服镁补充剂减少心脏手术后胃肠道并发症的发生率:一项随机临床试验。
胃肠道并发症是冠状动脉搭桥术后常见的并发症。这些并发症包括恶心、呕吐、肠系膜缺血和肝功能衰竭。恶心、呕吐和便秘似乎都与缺镁有关。本研究旨在探讨口服镁补充剂对心脏手术患者胃肠道并发症发生率的影响。在一项单盲随机临床试验中,102例接受冠状动脉搭桥手术的患者随机分为两组,干预组52例,对照组50例。实验组患者从入院到出院,每天给予800毫克氧化镁(2片,每片含240毫克元素镁)。比较两组患者术后恶心呕吐、便秘、心房颤动的发生率。我们的结果显示,干预组和对照组患者术后低镁血症发生率分别为41.20%和70.80%。便秘的总发生率为62%。补充镁的患者较少出现房颤、恶心、呕吐和便秘。我们的数据显示,口服镁补充剂可以减少术后并发症。尽管干预组患者的状态较好,但许多干预组患者仍存在低镁血症。似乎需要更高剂量的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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