{"title":"A Systematic Review of the Management of Incidental Findings in Genomic Research.","authors":"Cornelius Ewuoso","doi":"10.20541/beonline.2016.0006","DOIUrl":null,"url":null,"abstract":"<p><p>Information empowerment has been the greatest gain of genomics, yet it also poses serious threat to its survival, especially when the information is incidental. There may be an emerging consensus that actionable incidental findings be returned. But this has not been supported by any systematic review. Future directions are equally missing. These are significant gaps. To fill these gaps, an online search on PubMed and Genetics in Medicine website was conducted between 20th of August to 23rd of October, 2013; combining certain filters and phrases, such as 'return incidental findings'. Nineteen (19) articles were selected from an avalanche of results, and reviewed. The review confirms a majority support for return of clinically actionable findings. The result also shows that the support represents views of Northern Americans. Critical contributions of Africans, Asians and Europeans are missing in this discourse. I recommended studies in this direction.</p>","PeriodicalId":89895,"journal":{"name":"BEOnline : journal of the West African bioethics training program","volume":"3 1","pages":"1-21"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370178/pdf/","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BEOnline : journal of the West African bioethics training program","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20541/beonline.2016.0006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/11/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Information empowerment has been the greatest gain of genomics, yet it also poses serious threat to its survival, especially when the information is incidental. There may be an emerging consensus that actionable incidental findings be returned. But this has not been supported by any systematic review. Future directions are equally missing. These are significant gaps. To fill these gaps, an online search on PubMed and Genetics in Medicine website was conducted between 20th of August to 23rd of October, 2013; combining certain filters and phrases, such as 'return incidental findings'. Nineteen (19) articles were selected from an avalanche of results, and reviewed. The review confirms a majority support for return of clinically actionable findings. The result also shows that the support represents views of Northern Americans. Critical contributions of Africans, Asians and Europeans are missing in this discourse. I recommended studies in this direction.
信息授权是基因组学的最大收获，但它也对基因组学的生存构成严重威胁，特别是当信息是偶然的时候。可能正在形成一种共识，即应退还可采取行动的偶然发现。但这还没有得到任何系统评价的支持。未来的发展方向也同样缺失。这些都是显著的差距。为了填补这些空白，我们在2013年8月20日至10月23日期间对PubMed和Genetics in Medicine网站进行了在线搜索;结合某些过滤器和短语，如“返回偶然发现”。十九(19)篇文章从雪崩的结果中选出，并进行了审查。该综述证实，大多数人支持临床可操作的发现。调查结果还显示，这些支持代表了北美人的观点。非洲人、亚洲人和欧洲人的重要贡献在这一论述中被忽略了。我建议在这个方向上进行研究。
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