A concise review of common animal models for the study of limb regeneration.

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Organogenesis Pub Date : 2016-07-02 Epub Date: 2016-07-08 DOI:10.1080/15476278.2016.1205775
Zayd Farah, Huimin Fan, Zhongmin Liu, Jia-Qiang He
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引用次数: 11

Abstract

Correct selection of an appropriate animal mode to closely mimic human extremity diseases or to exhibit desirable phenotypes of limb regeneration is the first critical step for all scientists in biomedical and regenerative researches. The commonly-used animals in limb regeneration and repairing studies, such as axolotl, mice, and rats, are discussed in the review and other models including cockroaches, dogs, and horses are also mentioned. The review weighs the general advantages, disadvantages, and precedent uses of each model in the context of limb and peripheral injury and subsequent regeneration. We hope that this review can provide the reader an overview of each model, from which to select one for their specific purpose.

Abstract Image

简要综述用于肢体再生研究的常用动物模型。
正确选择合适的动物模型来模拟人类肢体疾病或展示理想的肢体再生表型是生物医学和再生研究的所有科学家的第一步。本文讨论了在肢体再生和修复研究中常用的动物,如蝾螈、小鼠和大鼠,并提到了蟑螂、狗和马等其他动物。这篇综述在肢体和外周损伤及随后的再生的背景下权衡了每种模型的一般优点、缺点和先例。我们希望这篇评论可以为读者提供每个模型的概述,从中选择一个适合他们特定目的的模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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