Myocarditis in a patient on Clozapine: What did it?

Q4 Medicine
Sahil Munjal, Stephen Ferrando
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引用次数: 0

Abstract

We are presenting a case of 37-year-old male with schizoaffective disorder who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. The patient also had a positive titer for Influenza A which makes it a diagnostic dilemma regarding the cause of his myocarditis. It may be possible that the myocarditis was caused by the Influenza A virus or synergistically exacerbated the clozapine's propensity to cause it. Currently, there are no studies establishing the link between the two etiologies. As clozapine can be the only option for patients resistant to treatment of their psychiatric illness and there being some evidence for successful re-challenge of clozapine, we consider that this patient could have benefitted from a trial of a re-challenge, however, was lost to follow up.

一名服用氯氮平的患者出现心肌炎:是什么引起的?
我们在此介绍一例患有精神分裂症的 37 岁男性患者,他在开始服用氯氮平治疗耐药精神病的 3 周内患上了心肌炎。该患者的甲型流感滴度也呈阳性,这使其心肌炎的病因诊断陷入困境。心肌炎有可能是由甲型流感病毒引起的,也有可能是氯氮平的协同作用加剧了心肌炎。目前,还没有研究证实这两种病因之间存在联系。由于氯氮平可能是对精神疾病治疗产生抗药性的患者的唯一选择,而且有证据表明重新挑战氯氮平是成功的,因此我们认为该患者本可以从重新挑战试验中获益,但却失去了随访机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Schizophrenia and Related Psychoses
Clinical Schizophrenia and Related Psychoses Medicine-Psychiatry and Mental Health
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期刊介绍: The vision of the exciting new peer-reviewed quarterly publication Clinical Schizophrenia & Related Psychoses (CS) is to provide psychiatrists and other healthcare professionals with the latest research and advances in the diagnosis and treatment of schizophrenia and related psychoses. CS is a practice-oriented publication focused exclusively on the newest research findings, guidelines, treatment protocols, and clinical trials relevant to patient care.
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