The Wide and Complex Field of NAFLD Biomarker Research: Trends.

ISRN hepatology Pub Date : 2014-04-28 eCollection Date: 2014-01-01 DOI:10.1155/2014/846923

Erika Wichro, Tanja Macheiner, Jasmin Schmid, Barbara Kavsek, Karine Sargsyan

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引用次数: 1

Abstract

Background. Nonalcoholic fatty liver disease is now acknowledged as a complex public health issue linked to sedentary lifestyle, obesity, and related disorders like type 2 diabetes and metabolic syndrome. Aims. We aimed to retrieve its trends out of the huge amount of published data. Therefore, we conducted an extensive literature search to identify possible biomarker and/or biomarker combinations by retrospectively assessing and evaluating common and novel biomarkers to predict progression and prognosis of obesity related liver diseases. Methodology. We analyzed finally 62 articles accounting for 157 cohorts and 45,288 subjects. Results. Despite the various approaches, most cohorts were considerably small and rarely comparable. Also, we found that the same standard parameters were measured rather than novel biomarkers. Diagnostics approaches appeared incomparable. Conclusions. Further collaborative investigations on harmonizing ways of data acquisition and identifying such biomarkers for clinical use are necessary to yield sufficient significant results of potential biomarkers.

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NAFLD生物标志物研究的广泛和复杂领域:趋势。

背景。非酒精性脂肪肝现在被认为是一个复杂的公共卫生问题，与久坐不动的生活方式、肥胖以及2型糖尿病和代谢综合征等相关疾病有关。目标我们的目标是从大量已发表的数据中检索其趋势。因此，我们进行了广泛的文献检索，通过回顾性评估和评估常见和新型生物标志物来预测肥胖相关肝脏疾病的进展和预后，以确定可能的生物标志物和/或生物标志物组合。方法。我们最终分析了62篇文章，涉及157个队列和45288名受试者。结果。尽管采用了各种方法，但大多数队列都相当小，很少具有可比性。此外，我们发现测量的是相同的标准参数，而不是新的生物标志物。诊断方法似乎无可比拟。结论。为了获得足够的潜在生物标志物的重要结果，有必要进一步合作研究协调数据获取方式和识别临床使用的这些生物标志物。

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ISRN hepatology

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