Brain activation differences in schizophrenia during context-dependent processing of saccade tasks.

IF 4.7 2区心理学 Q1 BEHAVIORAL SCIENCES

Behavioral and Brain Functions Pub Date : 2016-06-24 DOI:10.1186/s12993-016-0103-2

A L Rodrigue, B P Austin, K A Dyckman, J E McDowell

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引用次数: 6

Abstract

Background: Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades).

Results: Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group.

Conclusions: Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.

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精神分裂症患者在扫视任务情境依赖加工过程中的脑激活差异。

背景:精神分裂症患者的脑功能已经通过扫视范式和功能磁共振成像进行了探讨，但关于任务情境变化如何影响扫视相关的脑激活和行为表现的信息很少。我们招募了精神分裂症和比较受试者在不同的情境下执行扫视任务:(1)两个单任务(反扫视或亲扫视与注视交替)和(2)一个双任务(反扫视与亲扫视交替)。结果:使用ROI分析评估了眼跳回路的上下文依赖性差异。跨情境(单任务和双任务)的反扫视激活和前扫视激活的区别表明，精神分裂症组对情境的反应方式与对照组不同。结论:进一步研究背景加工对大脑激活和扫视表现的影响，为该疾病的认知缺陷模型提供信息，并加强对抗扫视作为精神分裂症潜在内表型的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioral and Brain Functions 医学-行为科学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.