Conservation and tissue-specific transcription patterns of long noncoding RNAs.

Journal of human transcriptome Pub Date : 2015-01-01 Epub Date: 2015-08-10 DOI:10.3109/23324015.2015.1077591
Melanie Ward, Callum McEwan, James D Mills, Michael Janitz
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引用次数: 75

Abstract

Over the past decade, the focus of molecular biology has shifted from being predominately DNA and protein-centric to having a greater appreciation of RNA. It is now accepted that the genome is pervasively transcribed in tissue- and cell-specific manner, to produce not only protein-coding RNAs, but also an array of noncoding RNAs (ncRNAs). Many of these ncRNAs have been found to interact with DNA, protein and other RNA molecules where they exert regulatory functions. Long ncRNAs (lncRNAs) are a subclass of ncRNAs that are particularly interesting due to their cell-specific and species-specific expression patterns and unique conservation patterns. Currently, individual lncRNAs have been classified functionally; however, for the vast majority the functional relevance is unknown. To better categorize lncRNAs, an understanding of their specific expression patterns and evolutionary constraints are needed.

Abstract Image

长链非编码rna的保护和组织特异性转录模式。
在过去的十年中,分子生物学的重点已经从主要以DNA和蛋白质为中心转移到对RNA有更多的欣赏。目前,人们普遍认为基因组以组织和细胞特异性的方式转录,不仅产生蛋白质编码rna,还产生一系列非编码rna (ncRNAs)。许多这些ncrna已被发现与DNA、蛋白质和其他RNA分子相互作用,在那里它们发挥调节功能。长链ncrna (lncrna)是ncrna的一个亚类,由于其细胞特异性和物种特异性表达模式和独特的保护模式而特别有趣。目前,单个lncrna已被功能分类;然而,对于绝大多数的功能相关性是未知的。为了更好地对lncrna进行分类,需要了解它们的特定表达模式和进化限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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