Neuroprotective effects of niosomes loaded with thymoquinone in the cerebral ischemia model of male Wistar rats

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-02-01 DOI:10.1016/j.nano.2022.102637

Somayyeh Hatami Nemati Ph.D candidate , Mohammad Reza Bigdeli Ph.D , Fatemeh Mortazavi Moghadam Ph.D , Kazem Sharifi Ph.D

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引用次数: 2

Abstract

The complex stroke pathophysiology, like oxidative stress and inflammatory reactions, causes substantially challenged in stroke treatment. Thymoquinone (TQ) is attributed to pharmacological actions like antioxidant and anti-inflammation. Thymoquinone is chemically hydrophobic, which causes poor solubility and bioavailability. To overcome this challenge Thymoquinone niosome was applied in this in-vivo study. The results demonstrated a significant reduction in rats treated with Thymoquinone niosome compared to free Thymoquinone and control groups (SOD), (TAC), and (GPX) activities were increased in the TQN group compared to the MCAO control group. The decrease in (MDA) level was seen in the Thymoquinone niosome group compared to the MCAO control group. The inflammation factors expression rates of IL-IB, IL-6, TNFα in I/R Thymoquinone niosome group were decreased. This study indicated that Thymoquinone niosome might be utilized as a promising novel carrier to improve Thymoquinone bioavailability and therapeutic effect in treating cerebral I/R injury.

Abstract Image

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载百里醌脑小体对雄性Wistar大鼠脑缺血模型的神经保护作用

复杂的脑卒中病理生理，如氧化应激和炎症反应，给脑卒中治疗带来了很大的挑战。百里醌(TQ)具有抗氧化和抗炎等药理作用。百里醌在化学上是疏水性的，这导致溶解度和生物利用度差。为了克服这一挑战，在体内研究中应用了百里醌niosome。结果表明，与游离百里醌组和对照组相比，经百里醌niosome处理的大鼠(SOD)、(TAC)和(GPX)活性显著降低，TQN组与MCAO对照组相比，SOD、(TAC)和(GPX)活性升高。与MCAO对照组相比，百里醌niosome组MDA水平明显降低。I/R百里醌niosome组炎症因子IL-IB、IL-6、tnf - α表达率降低。研究表明，百里醌niosome有望作为一种新型载体，提高百里醌在脑I/R损伤中的生物利用度和治疗效果。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.