A novel bidirectional perfusion-like administered system for NIR-II fluorescence imaging precision diagnosis of bladder cancer

IF 4.7 4区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Shilei Ren PhD , Rong Dai PhD , Ziliang Zheng PhD , Qin Liu PhD , Xiaochun Zheng MSc , Juan Li MSc , Shutong Wu MSc , Ruiping Zhang PhD , Zhiguo Gui PhD
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引用次数: 2

Abstract

Intravesical instillation has been considered an efficient route for detecting bladder cancer. However, only a small fraction of administered dose permeates into tumor tissues, and insufficient retention time limits their application. In this work, a novel intravesical bidirectional perfusion-like administered mode was developed to improve diagnostic accuracy of bladder tumor imaging. Specifically, the ultrasmall AuPd-P-FA Nanoprobe exhibit excellent NIR-II FL imaging performance due to electronic structure perturbation. Benefiting from the size advantage for kidney metabolism and FA targeting specificity, AuPd-P-FA could effectively administration to bladder tumor. When AuPd-P-FA reached maximum enrichment at 1 h post-injection, the localized and mild thermal energy produced upon laser irradiation activated a phase transition. This thermo-sensitive characteristic could prolong the retention time in bladder and the fluorescence signal could be clearly observed at 6 h post-injection with high accuracy. This novel intravesical bidirectional perfusion-like administered mode is expected to achieve a non-invasive diagnosis of early bladder cancer.

Abstract Image

一种新型双向灌注样给药系统用于NIR-II荧光成像膀胱癌的精确诊断
膀胱内灌注被认为是检测膀胱癌的有效途径。然而,只有一小部分给药剂量渗透到肿瘤组织中,并且保留时间不足限制了它们的应用。在这项工作中,一种新的膀胱内双向灌注给药模式被开发,以提高膀胱肿瘤成像的诊断准确性。具体来说,由于电子结构的扰动,超小的AuPd-P-FA纳米探针表现出优异的NIR-II FL成像性能。得益于肾脏代谢的大小优势和FA靶向特异性,AuPd-P-FA可有效给药膀胱肿瘤。当AuPd-P-FA在注射后1 h达到最大富集时,激光照射产生的局部温和热能激活了相变。这种热敏特性延长了在膀胱中的滞留时间,注射后6 h荧光信号清晰,准确度高。这种新型膀胱内双向灌注样给药模式有望实现早期膀胱癌的非侵入性诊断。
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来源期刊
CiteScore
8.10
自引率
3.60%
发文量
104
审稿时长
4.6 months
期刊介绍: Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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